Bibliographic Details
| Title: |
Mechanisms of the incretin effect in subjects with normal glucose tolerance and patients with type 2 diabetes. |
| Authors: |
Andrea Mari, Jonatan I Bagger, Ele Ferrannini, Jens J Holst, Filip K Knop, Tina Vilsbøll |
| Source: |
PLoS ONE, Vol 8, Iss 9, p e73154 (2013) |
| Publisher Information: |
Public Library of Science (PLoS), 2013. |
| Publication Year: |
2013 |
| Collection: |
LCC:Medicine
LCC:Science |
| Subject Terms: |
Medicine, Science |
| More Details: |
The incretin effect on insulin secretion was investigated in 8 subjects with type 2 diabetes (T2D) and 8 with normal glucose tolerance (NGT), using 25, 75, and 125 g oral glucose tolerance tests (OGTT) and isoglycemic intravenous glucose infusions (IIGI). The ß-cell response was evaluated using a model embedding a dose-response (slope=glucose sensitivity), an early response (rate sensitivity), and potentiation (time-related secretion increase). The incretin effect, as OGTT/IIGI ratio, was calculated for each parameter. In NGT, the incretin effect on total secretion increased with dose (1.3 ± 0.1, 1.7 ± 0.2, 2.2 ± 0.2 fold of IIGI, P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1932-6203 |
| Relation: |
http://europepmc.org/articles/PMC3760909?pdf=render; https://doaj.org/toc/1932-6203 |
| DOI: |
10.1371/journal.pone.0073154 |
| Access URL: |
https://doaj.org/article/364e4a8c6f4942f290823766a5d42baa |
| Accession Number: |
edsdoj.364e4a8c6f4942f290823766a5d42baa |
| Database: |
Directory of Open Access Journals |
