Academic Journal
Deep learning-based scoring of tumour-infiltrating lymphocytes is prognostic in primary melanoma and predictive to PD-1 checkpoint inhibition in melanoma metastasesResearch in context
| Title: | Deep learning-based scoring of tumour-infiltrating lymphocytes is prognostic in primary melanoma and predictive to PD-1 checkpoint inhibition in melanoma metastasesResearch in context |
|---|---|
| Authors: | Eftychia Chatziioannou, Jana Roßner, Thazin New Aung, David L. Rimm, Heike Niessner, Ulrike Keim, Lina Maria Serna-Higuita, Irina Bonzheim, Luis Kuhn Cuellar, Dana Westphal, Julian Steininger, Friedegund Meier, Oltin Tiberiu Pop, Stephan Forchhammer, Lukas Flatz, Thomas Eigentler, Claus Garbe, Martin Röcken, Teresa Amaral, Tobias Sinnberg |
| Source: | EBioMedicine, Vol 93, Iss , Pp 104644- (2023) |
| Publisher Information: | Elsevier, 2023. |
| Publication Year: | 2023 |
| Collection: | LCC:Medicine LCC:Medicine (General) |
| Subject Terms: | Cutaneous melanoma, Prognostic biomarkers, Predictive biomarkers, Tumour-infiltrating lymphocytes, Digital pathology, Medicine, Medicine (General), R5-920 |
| More Details: | Summary: Background: Recent advances in digital pathology have enabled accurate and standardised enumeration of tumour-infiltrating lymphocytes (TILs). Here, we aim to evaluate TILs as a percentage electronic TIL score (eTILs) and investigate its prognostic and predictive relevance in cutaneous melanoma. Methods: We included stage I to IV cutaneous melanoma patients and used hematoxylin-eosin-stained slides for TIL analysis. We assessed eTILs as a continuous and categorical variable using the published cut-off of 16.6% and applied Cox regression models to evaluate associations of eTILs with relapse-free, distant metastasis-free, and overall survival. We compared eTILs of the primaries with matched metastasis. Moreover, we assessed the predictive relevance of eTILs in therapy-naïve metastases according to the first-line therapy. Findings: We analysed 321 primary cutaneous melanomas and 191 metastatic samples. In simple Cox regression, tumour thickness (p 12.2% was associated with longer progression-free survival (p = 0.037) and melanoma-specific survival (p = 0.0038) in patients treated with anti-PD-1-based immunotherapy. In multiple Cox regression, lactate dehydrogenase (p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2352-3964 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2352396423002098; https://doaj.org/toc/2352-3964 |
| DOI: | 10.1016/j.ebiom.2023.104644 |
| Access URL: | https://doaj.org/article/35c191c0b266487cb0126f25360675a8 |
| Accession Number: | edsdoj.35c191c0b266487cb0126f25360675a8 |
| Database: | Directory of Open Access Journals |
| ISSN: | 23523964 |
|---|---|
| DOI: | 10.1016/j.ebiom.2023.104644 |
| Published in: | EBioMedicine |
| Language: | English |