Academic Journal
Convergent trends and spatiotemporal patterns of Aedes-borne arboviruses in Mexico and Central America.
| Title: | Convergent trends and spatiotemporal patterns of Aedes-borne arboviruses in Mexico and Central America. |
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| Authors: | Bernardo Gutierrez, Darlan da Silva Candido, Sumali Bajaj, Abril Paulina Rodriguez Maldonado, Fabiola Garces Ayala, María de la Luz Torre Rodriguez, Adnan Araiza Rodriguez, Claudia Wong Arámbula, Ernesto Ramírez González, Irma López Martínez, José Alberto Díaz-Quiñónez, Mauricio Vázquez Pichardo, Sarah C Hill, Julien Thézé, Nuno R Faria, Oliver G Pybus, Lorena Preciado-Llanes, Arturo Reyes-Sandoval, Moritz U G Kraemer, Marina Escalera-Zamudio |
| Source: | PLoS Neglected Tropical Diseases, Vol 17, Iss 9, p e0011169 (2023) |
| Publisher Information: | Public Library of Science (PLoS), 2023. |
| Publication Year: | 2023 |
| Collection: | LCC:Arctic medicine. Tropical medicine LCC:Public aspects of medicine |
| Subject Terms: | Arctic medicine. Tropical medicine, RC955-962, Public aspects of medicine, RA1-1270 |
| More Details: | BackgroundAedes-borne arboviruses cause both seasonal epidemics and emerging outbreaks with a significant impact on global health. These viruses share mosquito vector species, often infecting the same host population within overlapping geographic regions. Thus, comparative analyses of the virus evolutionary and epidemiological dynamics across spatial and temporal scales could reveal convergent trends.Methodology/principal findingsFocusing on Mexico as a case study, we generated novel chikungunya and dengue (CHIKV, DENV-1 and DENV-2) virus genomes from an epidemiological surveillance-derived historical sample collection, and analysed them together with longitudinally-collected genome and epidemiological data from the Americas. Aedes-borne arboviruses endemically circulating within the country were found to be introduced multiple times from lineages predominantly sampled from the Caribbean and Central America. For CHIKV, at least thirteen introductions were inferred over a year, with six of these leading to persistent transmission chains. For both DENV-1 and DENV-2, at least seven introductions were inferred over a decade.Conclusions/significanceOur results suggest that CHIKV, DENV-1 and DENV-2 in Mexico share evolutionary and epidemiological trajectories. The southwest region of the country was determined to be the most likely location for viral introductions from abroad, with a subsequent spread into the Pacific coast towards the north of Mexico. Virus diffusion patterns observed across the country are likely driven by multiple factors, including mobility linked to human migration from Central towards North America. Considering Mexico's geographic positioning displaying a high human mobility across borders, our results prompt the need to better understand the role of anthropogenic factors in the transmission dynamics of Aedes-borne arboviruses, particularly linked to land-based human migration. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1935-2727 1935-2735 |
| Relation: | https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0011169&type=printable; https://doaj.org/toc/1935-2727; https://doaj.org/toc/1935-2735 |
| DOI: | 10.1371/journal.pntd.0011169&type=printable |
| DOI: | 10.1371/journal.pntd.0011169 |
| Access URL: | https://doaj.org/article/c35b09f0aff4488494d43b69f4964ffc |
| Accession Number: | edsdoj.35b09f0aff4488494d43b69f4964ffc |
| Database: | Directory of Open Access Journals |
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| ISSN: | 19352727 19352735 |
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| DOI: | 10.1371/journal.pntd.0011169&type=printable |
| Published in: | PLoS Neglected Tropical Diseases |
| Language: | English |