Bibliographic Details
| Title: |
Effectiveness of inhaled therapies in asthma among adults in Northern Sri Lanka, a low-income and middle-income country: a prospective observational study |
| Authors: |
Shalini Sri Ranganathan, Yalini Guruparan, Thiyahiny S Navaratinaraja, Gowry Selvaratnam |
| Source: |
BMJ Open Respiratory Research, Vol 12, Iss 1 (2025) |
| Publisher Information: |
BMJ Publishing Group, 2025. |
| Publication Year: |
2025 |
| Collection: |
LCC:Medicine
LCC:Diseases of the respiratory system |
| Subject Terms: |
Medicine, Diseases of the respiratory system, RC705-779 |
| More Details: |
Background Inhaled corticosteroids (ICS) alone, or combined with long-acting beta2-agonist (LABA), are recommended for chronic asthma. Limited access to inhaled medications hinders effective control of asthma in low-income and middle-income countries.Objective This study aimed to compare the effectiveness of inhaled therapies in a cohort of adult patients with asthma who were receiving treatment in a tertiary hospital in Northern Sri Lanka.Methods A prospective cohort study was conducted among adult patients with asthma on either ICS alone or ICS/LABA combination for at least 3 months. Participants were followed up for 6 months, with two follow-up interviews conducted 3 months apart. The primary outcome measure was asthma control, assessed by a locally validated asthma control patient-reported outcome measure. Secondary outcome measures included the use of short-acting beta2-agonists (SABA) and the percentage of patients required nebulisations and hospitalisations. McNemar’s test was used to determine the statistical significance. A p value≤0.05 was considered significant.Results Of the 1094 participants, 827 (76%) were on ICS monotherapy and 267 (24%) were on ICS/LABA. Though there were no changes in the treatment, progressive improvement in asthma control was observed from baseline to second follow-up in both ICS (54%–72%) and ICS/LABA (76%–81%) groups. Significant improvement in asthma control (p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2052-4439 |
| Relation: |
https://bmjopenrespres.bmj.com/content/12/1/e002675.full; https://doaj.org/toc/2052-4439 |
| DOI: |
10.1136/bmjresp-2024-002675 |
| Access URL: |
https://doaj.org/article/ea350ad82a1b47ceb5e7d66a21b58969 |
| Accession Number: |
edsdoj.350ad82a1b47ceb5e7d66a21b58969 |
| Database: |
Directory of Open Access Journals |
