Bibliographic Details
| Title: |
Infective intracardiac lesion in the setting of Mycobacterium franklinii bacteremia identified by cell-free DNA sequencing in a child with acute lymphoblastic leukemia: A potential new foe in intracardiac infections |
| Authors: |
Khalifah A. Aldawsari, Evelina Dedic, Braden Olsen, Haneen Y. Abdella, Manuel R. Cotilla, Danyal M. Khan |
| Source: |
IDCases, Vol 34, Iss , Pp e01905- (2023) |
| Publisher Information: |
Elsevier, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Infectious and parasitic diseases |
| Subject Terms: |
Mycobacterium cheloanae-abscessus complex, Mycobacterium franklinii, Cardiac thrombus, Microbial cell-free DNA sequencing, Infectious and parasitic diseases, RC109-216 |
| More Details: |
Mycobacterium franklinii (Mfra) is a recently identified member of the Mycobacterium chelonae-abscessus complex (MCAC), a rapidly growing, acid-fast bacilli that have the potential to cause invasive human infections. Identification of Mfra is crucial for selecting the appropriate antimicrobial therapy, as Mfra displays a unique susceptibility profile compared to other MCAC members. The literature on Mfra is limited, with a few studies focusing on respiratory and skin infections. To our knowledge, we describe the first reported case of cardiac involvement associated with Mfra bacteremia in a patient with acute lymphoblastic leukemia. The isolation of Mfra through a next-generation sequencing test allowed for prompt identification and subsequent implementation of tailored antimicrobial agents, ultimately resulting in positive clinical outcomes. This case also emphasizes the significance of next-generation testing in managing immunocompromised patients with persistent fever. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2214-2509 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2214250923002299; https://doaj.org/toc/2214-2509 |
| DOI: |
10.1016/j.idcr.2023.e01905 |
| Access URL: |
https://doaj.org/article/a3505d4eaee746238204a3bb0814a8bc |
| Accession Number: |
edsdoj.3505d4eaee746238204a3bb0814a8bc |
| Database: |
Directory of Open Access Journals |
