Bibliographic Details
| Title: |
The Effect of Aging on Retinal Function and Retinal Ganglion Cell Morphology Following Intraocular Pressure Elevation |
| Authors: |
Pei Ying Lee, Da Zhao, Vickie H. Y. Wong, Vicki Chrysostomou, Jonathan G. Crowston, Bang V. Bui |
| Source: |
Frontiers in Aging Neuroscience, Vol 14 (2022) |
| Publisher Information: |
Frontiers Media S.A., 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| Subject Terms: |
aging, intraocular pressure, retinal ganglion cells, recovery, electroretinogram, morphology, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| More Details: |
Aging and elevated intraocular pressure (IOP) are two major risk factors for glaucomatous optic neuropathy; a condition characterized by the selective, progressive injury, and subsequent loss of retinal ganglion cells (RGCs). We examined how age modified the capacity for RGCs to functionally recover following a reproducible IOP elevation (50 mmHg for 30 min). We found that RGC functional recovery (measured using electroretinography) was complete by 7 days in 3-month-old mice but was delayed in 12-month-old mice until 14 days. At the 7-day recovery endpoint when RGC function had recovered in young but not older eyes, we examined RGC structural responses to IOP-related stress by analyzing RGC dendritic morphology. ON-RGC cell volume was attenuated following IOP elevation in both young and older mice. We also found that following IOP elevation OFF-RGC dendritic morphology became less complex per cell volume in young mice, an effect that was not observed in older eyes. Our data suggest that adaptations in OFF-RGCs in young eyes were associated with better functional recovery 7 days after IOP elevation. Loss of RGC cellular adaptations may account for delayed functional recovery in older eyes. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1663-4365 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fnagi.2022.859265/full; https://doaj.org/toc/1663-4365 |
| DOI: |
10.3389/fnagi.2022.859265 |
| Access URL: |
https://doaj.org/article/3468887849d840659285d4246cc02d29 |
| Accession Number: |
edsdoj.3468887849d840659285d4246cc02d29 |
| Database: |
Directory of Open Access Journals |
