Role of early increase in vascular endothelial growth factor-A levels after coronary stenting in the development of drug-eluting in-stent restenosis
| Title: | Role of early increase in vascular endothelial growth factor-A levels after coronary stenting in the development of drug-eluting in-stent restenosis |
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| Authors: | V. V. Tishko, E. I. Senkina, M. E. Meshkova, A. N. Shishkevich, I. A. Menkova, S. E. Bednova, V. V. Tyrenko |
| Source: | Кардиоваскулярная терапия и профилактика, Vol 23, Iss 5 (2024) |
| Publisher Information: | «SILICEA-POLIGRAF» LLC, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Diseases of the circulatory (Cardiovascular) system |
| Subject Terms: | percutaneous coronary angioplasty, drug-eluting stent(s), in-stent restenosis, vascular endothelial growth factor-a, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| More Details: | The introduction of drug-eluting stents (DES) into clinical practice has led to a significant reduction in the incidence of in-stent restenosis (ISR) compared to implantation of bare metal stents. However, in 2-4% of cases, the development of angiographic restenosis is observed. Vascular Endothelial Growth Factor-A (VEGF-A) promotes early endothelialization of the stented segment, but in some cases can promote progressive neointimal growth due to proinflammatory effects.Aim. To evaluate the influence of plasma VEGF-A level on ISR after DES implantation.Material and methods. We prospectively examined 49 patients who were implanted with DES due to stable coronary artery disease with ischemia-related arterial stenosis >70% according to a stress test, as well as with a fractional flow reserve 0,05). Within 24 hours after stent implantation, a significant increase in VEGF-A level was found in patients who subsequently demonstrated angiographic ISR as follows: from 476 (267; 602) to 1117 (1089; 1573) pg/ml (p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | Russian |
| ISSN: | 1728-8800 2619-0125 |
| Relation: | https://cardiovascular.elpub.ru/jour/article/view/3904; https://doaj.org/toc/1728-8800; https://doaj.org/toc/2619-0125 |
| DOI: | 10.15829/1728-8800-2024-3904 |
| Access URL: | https://doaj.org/article/34639cdab360475b8760f87d96344d2f |
| Accession Number: | edsdoj.34639cdab360475b8760f87d96344d2f |
| Database: | Directory of Open Access Journals |
| ISSN: | 17288800 26190125 |
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| DOI: | 10.15829/1728-8800-2024-3904 |
| Published in: | Кардиоваскулярная терапия и профилактика |
| Language: | Russian |