Bibliographic Details
| Title: |
The relationship between triglyceride, cholesterol and lipoprotein levels, and immune responses to hepatitis B vaccine |
| Authors: |
Dan Guo, Jiazhen Dai, Rong Ju, Qifan Zhou, Nenghuan Wang, Chunhua Wu, Hui Tao, Hui Jing, Chen Zhu, Jinxian Mao, Jiayan Xu |
| Source: |
Frontiers in Medicine, Vol 10 (2023) |
| Publisher Information: |
Frontiers Media S.A., 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Medicine (General) |
| Subject Terms: |
hepatitis B vaccine, triglyceride (TG), cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), immune response, Medicine (General), R5-920 |
| More Details: |
Cholesterol homeostasis disorder and hypertriglyceridemia, as common metabolic conditions, have rarely been reported to affect the immune responses to the hepatitis B vaccine. Our study found that higher high-density lipoprotein (HDL) level showed a significant relationship with positive anti-HBs results (cOR = 1.479, 95% CI: 1.150, 1.901, p = 0.002; aOR = 1.304, 95% CI: 1.006, 1.691, p = 0.045), especially in individuals aged 18- to 40-year-old, female, smoking more than 100 cigarettes in life, and drinking more than 12 times every year. Lower low-density lipoprotein (LDL) level was associated with a negative anti-HBs result among participants aged 18- to 40-year-old, and participants who were obese. Higher level of HDL and lower level of LDL may be protective factors of better immune effect of hepatitis B vaccine. More research should be conducted to investigate the influence of the cholesterol level on the immune responses to the hepatitis B vaccine, and more in-depth research should be performed to uncover the mechanism. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2296-858X |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fmed.2023.1131373/full; https://doaj.org/toc/2296-858X |
| DOI: |
10.3389/fmed.2023.1131373 |
| Access URL: |
https://doaj.org/article/e340dcf05ca1446391d8972321a4437c |
| Accession Number: |
edsdoj.340dcf05ca1446391d8972321a4437c |
| Database: |
Directory of Open Access Journals |
