Novel monoclonal antibodies targeting the microtubule-binding domain of human tau.

Bibliographic Details
Title: Novel monoclonal antibodies targeting the microtubule-binding domain of human tau.
Authors: Cara L Croft, Brenda D Moore, Yong Ran, Paramita Chakrabarty, Yona Levites, Todd E Golde, Benoit I Giasson
Source: PLoS ONE, Vol 13, Iss 4, p e0195211 (2018)
Publisher Information: Public Library of Science (PLoS), 2018.
Publication Year: 2018
Collection: LCC:Medicine
LCC:Science
Subject Terms: Medicine, Science
More Details: Tauopathies including Alzheimer's disease and Progressive Supranuclear Palsy are a diverse group of progressive neurodegenerative disorders pathologically defined by inclusions containing aberrantly aggregated, post-translationally modified tau. The tau pathology burden correlates with neurodegeneration and dementia observed in these diseases. The microtubule binding domain of tau is essential for its physiological functions in promoting neuronal cytoskeletal stability, however it is also required for tau to assemble into an amyloid structure that comprises pathological inclusions. A series of novel monoclonal antibodies were generated which recognize the second and fourth microtubule-binding repeat domain of tau, thus enabling the identification specifically of 4-repeat tau versus 3-/4-repeat tau, respectively. These antibodies are highly specific for tau and recognize pathological tau inclusions in human tauopathies including Alzheimer's disease and Progressive Supranuclear Palsy and in transgenic mouse models of tauopathies. These new antibodies will be useful for identifying and characterizing different tauopathies and as tools to target tau pathology in these diseases.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 1932-6203
Relation: http://europepmc.org/articles/PMC5880389?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0195211
Access URL: https://doaj.org/article/33df30cd1ad04095b1e8ac375eb2c2ad
Accession Number: edsdoj.33df30cd1ad04095b1e8ac375eb2c2ad
Database: Directory of Open Access Journals
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More Details
ISSN:19326203
DOI:10.1371/journal.pone.0195211
Published in:PLoS ONE
Language:English