Academic Journal
Ozone Partially Decreases Axonal and Myelin Damage in an Experimental Sciatic Nerve Injury Model
| Title: | Ozone Partially Decreases Axonal and Myelin Damage in an Experimental Sciatic Nerve Injury Model |
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| Authors: | Zahir Kızılay, Nesibe Kahraman Çetin, Mehran Aksel, Burçin İrem Abas, Serdar Aktaş, Haydar Ali Erken, Abdullah Topçu, Ali Yılmaz, Cigdem Yenisey |
| Source: | Journal of Investigative Surgery, Vol 32, Iss 1, Pp 8-17 (2019) |
| Publisher Information: | Taylor & Francis Group, 2019. |
| Publication Year: | 2019 |
| Collection: | LCC:Surgery |
| Subject Terms: | sciatic nerve, injury, yasargil aneurysm clip, nerve conduction velocity, ozone, healing, Surgery, RD1-811 |
| More Details: | Aim: To investigate the effects of ozone in experimental acute sciatic nerve injury. Material and Methods: Twenty-eight male rats were divided into four groups (n = 7): control (C), ozone (O), injury (SNI), and treatment with ozone after injury (SNI + Ozone). Sciatic nerve injury was generated by compressing the right sciatic nerve for 90 s using a Yasargil aneurysm clip in groups SNI and SNI + Ozone. A 70 µg/ml concentration of ozone was given four times (once a day at 1st, 24th, 48th, and 72th h) at a dose of 0.5 mg/kg to groups O and SNI + Ozone after injury by an intraperitoneal injection. Nerve conduction velocities of all rats were measured by in vivo electrophysiological tests at the end of the day 4. Then, plasma malondialdehyde, total oxidant and antioxidant status were measured and also axonal and myelin changes in sciatic nerves of histopathological examination were performed. The data were analyzed by Kolmogorov Smirnov test, Mann–Whitney U-test, and Chi square test. p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 0894-1939 1521-0553 08941939 |
| Relation: | https://doaj.org/toc/0894-1939; https://doaj.org/toc/1521-0553 |
| DOI: | 10.1080/08941939.2017.1369606 |
| Access URL: | https://doaj.org/article/c33af689e5654d04b4388c93833da8c7 |
| Accession Number: | edsdoj.33af689e5654d04b4388c93833da8c7 |
| Database: | Directory of Open Access Journals |
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| ISSN: | 08941939 15210553 |
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| DOI: | 10.1080/08941939.2017.1369606 |
| Published in: | Journal of Investigative Surgery |
| Language: | English |