Bibliographic Details
| Title: |
Fmoc-amino acid-based hydrogel vehicle for delivery of amygdalin to perform neuroprotection |
| Authors: |
Zhao-yu Yang, Yuan-yuan Zhong, Jun Zheng, Yilin Liu, Teng Li, En Hu, Xiao-fei Zhu, Ruo-qi Ding, Yao Wu, Yi Zhang, Tao Tang, Feng He, Shun-shun Wang, Yang Wang |
| Source: |
Smart Materials in Medicine, Vol 2, Iss , Pp 56-64 (2021) |
| Publisher Information: |
KeAi Communications Co., Ltd., 2021. |
| Publication Year: |
2021 |
| Collection: |
LCC:Technology |
| Subject Terms: |
Amygdalin, Complex hydrogel, Self-assembly, Fmoc-Tyr-OH anti-Inflammation, Neural regeneration, Technology |
| More Details: |
Amygdalin is widely distributed in the plant kingdom. Oral delivery of amygdalin releases hydrogen cyanide upon endogenous enzymes causing potential toxic effects to humans. Here, we fabricate Fmoc-Tyr–OH–amygdalin hydrogel (FTOA) which represents L-tyrosine derived low molecular weight hydrogelator entrapping amygdalin. Fourier Transform Infrared Spectroscopy and the Fluorescent Emission Spectrum elucidated the complexation process between the amygdalin and Fmoc-Tyr-OH (FTO). Amygdalin was sustainably released from FTOA at different pH buffer. The rheological behavior similar to the brain supported that the hydrogel tended to be a preferable neural scaffold. Moreover, animal studies showed FTOA significantly promoted neural-functional recovery. This hydrogel achieved a great decrease in damage volume according to H&E staining. Additionally, we found that FTOA enhanced tissue recovery. Simultaneously, the released amygdalin gave a markedly neural inflammatory suppression. Taken together, this study highlights that Fmoc-based gelator encapsulate amygdalin forming a stable hydrogel to perform sustained-release and improve efficacy with minimal side effects. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2590-1834 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2590183420300314; https://doaj.org/toc/2590-1834 |
| DOI: |
10.1016/j.smaim.2020.10.004 |
| Access URL: |
https://doaj.org/article/33a3d0c57fc3463ab4f7364f9706827e |
| Accession Number: |
edsdoj.33a3d0c57fc3463ab4f7364f9706827e |
| Database: |
Directory of Open Access Journals |
