Bibliographic Details
| Title: |
A case of ischemic stroke and transient thrombocytopenia in a young female following adenoviral vector-based COVID-19 vaccination: Was the association incidental or causal? |
| Authors: |
Shweta Pandey, Ravindra Kumar Garg, Pooja Tripathi, Hardeep S Malhotra, Neeraj Kumar |
| Source: |
Journal of Family Medicine and Primary Care, Vol 11, Iss 10, Pp 6556-6559 (2022) |
| Publisher Information: |
Wolters Kluwer Medknow Publications, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Medicine |
| Subject Terms: |
cerebral infarction, cerebral venous thrombosis, platelet factor-4, vaccine-induced thrombotic thrombocytopenia, Medicine |
| More Details: |
Since March 2021, cases with unusual clots, particularly cerebral venous sinus thrombosis and splanchnic vein thrombosis, have been reported worldwide following adenoviral vector-based coronavirus disease 2019 (COVID-19) vaccination. This entity has been termed vaccine-induced thrombotic thrombocytopenia (VITT). We report a 23-year-old healthy female who developed seizures, altered sensorium, and left hemiparesis, 20 days after receiving the first dose of adenoviral vector-based COVID-19 vaccine “Covishield™.” The patient had transient thrombocytopenia. The D-dimer level was 2460 ng/mL. Magnetic resonance imaging (MRI) demonstrated occlusion of M2 segment of the middle cerebral artery and cerebral infarction. Platelet factor-4 antibodies level was normal. Treatment with aspirin and antiepileptic drugs resulted in a remarkable recovery. This is the first Indian case report of ischemic stroke and transient thrombocytopenia following SARS-CoV-2 ChAdOx1 nCoV-19 vaccination. Our case had clinical features consistent with the diagnosis of probable VITT. Familiarity with VITT is crucial because timely treatment with non-heparin anticoagulants and intravenous immunoglobulin improves the outcome. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2249-4863 |
| Relation: |
http://www.jfmpc.com/article.asp?issn=2249-4863;year=2022;volume=11;issue=10;spage=6556;epage=6559;aulast=Pandey; https://doaj.org/toc/2249-4863 |
| DOI: |
10.4103/jfmpc.jfmpc_476_22 |
| Access URL: |
https://doaj.org/article/3358f3d474b044adac4bb6311df8d186 |
| Accession Number: |
edsdoj.3358f3d474b044adac4bb6311df8d186 |
| Database: |
Directory of Open Access Journals |
