Bibliographic Details
| Title: |
Intestinal Organoids: New Tools to Comprehend the Virulence of Bacterial Foodborne Pathogens |
| Authors: |
Mayra Aguirre Garcia, Killian Hillion, Jean-Michel Cappelier, Michel Neunlist, Maxime M. Mahe, Nabila Haddad |
| Source: |
Foods, Vol 11, Iss 1, p 108 (2022) |
| Publisher Information: |
MDPI AG, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Chemical technology |
| Subject Terms: |
pathogenic mechanism, foodborne bacteria, in vitro cell models, organoids, enteroids, Chemical technology, TP1-1185 |
| More Details: |
Foodborne diseases cause high morbidity and mortality worldwide. Understanding the relationships between bacteria and epithelial cells throughout the infection process is essential to setting up preventive and therapeutic solutions. The extensive study of their pathophysiology has mostly been performed on transformed cell cultures that do not fully mirror the complex cell populations, the in vivo architectures, and the genetic profiles of native tissues. Following advances in primary cell culture techniques, organoids have been developed. Such technological breakthroughs have opened a new path in the study of microbial infectious diseases, and thus opened onto new strategies to control foodborne hazards. This review sheds new light on cellular messages from the host–foodborne pathogen crosstalk during in vitro organoid infection by the foodborne pathogenic bacteria with the highest health burden. Finally, future perspectives and current challenges are discussed to provide a better understanding of the potential applications of organoids in the investigation of foodborne infectious diseases. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2304-8158 |
| Relation: |
https://www.mdpi.com/2304-8158/11/1/108; https://doaj.org/toc/2304-8158 |
| DOI: |
10.3390/foods11010108 |
| Access URL: |
https://doaj.org/article/d32b594429e44bd8b54e68bbc9135e2d |
| Accession Number: |
edsdoj.32b594429e44bd8b54e68bbc9135e2d |
| Database: |
Directory of Open Access Journals |
