| Title: |
Coronary Microvascular Dysfunction in Systemic Lupus Erythematosus |
| Authors: |
Brittany N. Weber, Emma Stevens, Leanne Barrett, Camden Bay, Corine Sinnette, Jenifer M. Brown, Sanjay Divakaran, Courtney Bibbo, Jon Hainer, Sharmila Dorbala, Ron Blankstein, Katherine Liao, Elena Massarotti, Karen Costenbader, Marcelo F. Di Carli |
| Source: |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 13 (2021) |
| Publisher Information: |
Wiley, 2021. |
| Publication Year: |
2021 |
| Collection: |
LCC:Diseases of the circulatory (Cardiovascular) system |
| Subject Terms: |
coronary microvascular dysfunction, inflammation, systemic lupus erythematosus, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| More Details: |
Background Systemic lupus erythematosus (SLE) is a systemic autoimmune inflammatory disorder associated with premature atherosclerosis and increased cardiovascular risk. Systemic inflammation is an emerging risk factor for coronary microvascular dysfunction (CMD). We aimed to test whether CMD, defined as abnormal myocardial flow reserve (MFR) by positron emission tomography‐computed tomography, would be independently associated with SLE after adjusting for nonobstructive atherosclerotic burden and common cardiovascular risk factors. Methods and Results Consecutive patients with SLE who underwent symptom‐prompted stress cardiac positron emission tomography‐computed tomography were included (n=42). Obstructive coronary artery disease and systolic dysfunction were excluded. MFR was quantified by positron emission tomography‐computed tomography, and CMD was defined as MFR |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2047-9980 |
| Relation: |
https://doaj.org/toc/2047-9980 |
| DOI: |
10.1161/JAHA.120.018555 |
| Access URL: |
https://doaj.org/article/32acf1307fff440e87c9bd1af4f2ad39 |
| Accession Number: |
edsdoj.32acf1307fff440e87c9bd1af4f2ad39 |
| Database: |
Directory of Open Access Journals |
