Bibliographic Details
| Title: |
B cell metabolism in autoimmune diseases: signaling pathways and interventions |
| Authors: |
Jingyue Li, Mingjiu Zhao, Wenjun Luo, Jiaqi Huang, Bin Zhao, Zhiguang Zhou |
| Source: |
Frontiers in Immunology, Vol 14 (2023) |
| Publisher Information: |
Frontiers Media S.A., 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Immunologic diseases. Allergy |
| Subject Terms: |
autoimmune diseases, autoimmunity, B cell, B cell metabolism, B cell differentiation and function, Immunologic diseases. Allergy, RC581-607 |
| More Details: |
Autoimmune diseases are heterogeneous disorders believed to stem from the immune system’s inability to distinguish between auto- and foreign- antigens. B lymphocytes serve a crucial role in humoral immunity as they generate antibodies and present antigens. Dysregulation of B cell function induce the onset of autoimmune disorders by generating autoantibodies and pro-inflammatory cytokines, resulting in an imbalance in immune regulation. New research in immunometabolism shows that cellular metabolism plays an essential role in controlling B lymphocytes immune reactions by providing the energy and substrates for B lymphocytes activation, differentiation, and function. However, dysregulated immunometabolism lead to autoimmune diseases by disrupting self-tolerance mechanisms. This review summarizes the latest research on metabolic reprogramming of B lymphocytes in autoimmune diseases, identifying crucial pathways and regulatory factors. Moreover, we consider the potential of metabolic interventions as a promising therapeutic strategy. Understanding the metabolic mechanisms of B cells brings us closer to developing novel therapies for autoimmune disorders. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1664-3224 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fimmu.2023.1232820/full; https://doaj.org/toc/1664-3224 |
| DOI: |
10.3389/fimmu.2023.1232820 |
| Access URL: |
https://doaj.org/article/3290f7c74ad84d54abacf9c5bbe2772b |
| Accession Number: |
edsdoj.3290f7c74ad84d54abacf9c5bbe2772b |
| Database: |
Directory of Open Access Journals |
