Bibliographic Details
| Title: |
Relationship between disorders of the intestinal microbiota and heart failure in infants with congenital heart disease |
| Authors: |
Qi-Liang Zhang, Xiu-Hua Chen, Si-Jia Zhou, Yu-Qing Lei, Jiang-Shan Huang, Qiang Chen, Hua Cao |
| Source: |
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023) |
| Publisher Information: |
Frontiers Media S.A., 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Microbiology |
| Subject Terms: |
heart failure, intestinal microbiota, congenital heart disease, disorders of microbiota, infants, Microbiology, QR1-502 |
| More Details: |
PurposeThere is a close relationship between the intestinal microbiota and heart failure, but no study has assessed this relationship in infants with congenital heart disease. This study aimed to explore the relationship between heart failure and intestinal microbiota in infants with congenital heart disease.MethodsTwenty-eight infants with congenital heart disease with heart failure admitted to a provincial children’s hospital from September 2021 to December 2021 were enrolled in this study. A total of 22 infants without heart disease and matched for age, sex, and weight were selected as controls. Faecal samples were collected from every participant and subjected to 16S rDNA gene sequencing.ResultsThe composition of the intestinal microbiota was significantly disordered in infants with heart failure caused by congenital heart disease compared with that in infants without heart disease. At the phylum level, the most abundant bacteria in the heart failure group were Firmicutes, Actinobacteria, Proteobacteria, and Bacteroidetes, and the most abundant bacteria in the control group were Firmicutes, Proteobacteria, Actinobacteria, and Bacteroidetes. At the genus level, the most abundant bacteria in the heart failure group were Enterococcus, Bifidobacterium, Subdoligranulum, Shigella, and Streptococcus, and the most abundant bacteria in the control group were Bifidobacterium, Blautia, Bacteroides, Streptococcus, and Ruminococcus. The alpha and beta diversities of the gut bacterial community in the heart failure group were significantly lower than those in the control group (p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2235-2988 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fcimb.2023.1152349/full; https://doaj.org/toc/2235-2988 |
| DOI: |
10.3389/fcimb.2023.1152349 |
| Access URL: |
https://doaj.org/article/3258171da99a4309b9eee755888982ed |
| Accession Number: |
edsdoj.3258171da99a4309b9eee755888982ed |
| Database: |
Directory of Open Access Journals |
