Sodium–glucose cotransporter 2 inhibition through henagliflozin ameliorates cognitive impairment in patients with type 2 diabetes
| Title: | Sodium–glucose cotransporter 2 inhibition through henagliflozin ameliorates cognitive impairment in patients with type 2 diabetes |
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| Authors: | Shujun Zhang, Fen Wang, Lei Xie, Jialu Xu, Xiaoqing Song, Jing Tao, Juan Chen, Delin Ma, Xuefeng Yu, Xiaoli Shi, Yan Yang |
| Source: | Journal of Diabetes Investigation, Vol 15, Iss 11, Pp 1596-1603 (2024) |
| Publisher Information: | Wiley, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Diseases of the endocrine glands. Clinical endocrinology |
| Subject Terms: | Cognitive impairment, Henagliflozin, Type 2 diabetes, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| More Details: | Abstract Aims/Introduction To assess whether the sodium–glucose cotransporter 2 inhibitor, henagliflozin, improves cognitive impairment in patients with type 2 diabetes. Materials and Methods We carried out a prospective study on 290 patients with type 2 diabetes and cognitive impairment. Montreal Cognitive Assessment scores and plasma phosphorylated tau181 levels were used to assess cognition. The association between henagliflozin use and changes in cognition was examined using multivariable logistic regression analysis. Results Montreal Cognitive Assessment scores at enrollment and after 6 months were 21 (interquartile range [IQR]19–23) versus 22 (IQR 20–25; P 0.05) in the non‐sodium–glucose cotransporter 2 inhibitor group. Logistic regression analysis showed that henagliflozin treatment was associated with Montreal Cognitive Assessment score improvement independent of potential confounders (odds ratio [OR] 3.670, 95% confidence interval [CI] 2.224–6.056, P |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2040-1124 2040-1116 |
| Relation: | https://doaj.org/toc/2040-1116; https://doaj.org/toc/2040-1124 |
| DOI: | 10.1111/jdi.14306 |
| Access URL: | https://doaj.org/article/322bd7944a9b43058ec41cf8c47d84d3 |
| Accession Number: | edsdoj.322bd7944a9b43058ec41cf8c47d84d3 |
| Database: | Directory of Open Access Journals |
| ISSN: | 20401124 20401116 |
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| DOI: | 10.1111/jdi.14306 |
| Published in: | Journal of Diabetes Investigation |
| Language: | English |