Bibliographic Details
| Title: |
Lipoprotein-associated phospholipase A2 levels, endothelial dysfunction and arterial stiffness in patients with stable coronary artery disease |
| Authors: |
Konstantinos Mourouzis, Gerasimos Siasos, Evangelos Oikonomou, Marina Zaromitidou, Vicky Tsigkou, Alexis Antonopoulos, Evanthia Bletsa, Panagiota Stampouloglou, Konstantinos Vlasis, Manolis Vavuranakis, Dimitris Tousoulis |
| Source: |
Lipids in Health and Disease, Vol 20, Iss 1, Pp 1-9 (2021) |
| Publisher Information: |
BMC, 2021. |
| Publication Year: |
2021 |
| Collection: |
LCC:Nutritional diseases. Deficiency diseases |
| Subject Terms: |
Lipoprotein-associated phospholipase A2, Endothelial dysfunction, Wave reflections, Coronary artery disease, Arterial stiffness, Nutritional diseases. Deficiency diseases, RC620-627 |
| More Details: |
Abstract Background Lipoprotein-associated Phospholipase A2 (Lp-PLA2), can exert proinflammatory as well as proatherogenic properties on the vascular wall. The current study sought to evaluate the influence of high Lp-PLA2 levels on indices of arterial wall properties in patients with stable coronary artery disease (CAD). Methods Three hundred seventy-four consecutive patients with stable CAD (mean age 61 ± 11 years, 89% males) were enrolled in this single-center cross-sectional study. Flow-mediated dilation (FMD) was used to assess endothelial function and augmentation index (AIx) of the central aortic pressure was used to assess reflected waves. ELISA was used to determine Lp-PLA2 serum levels. Results After dividing the participants in 3 equal groups based on the tertiles of circulating Lp-PLA2 values, no significant differences were demonstrated between those in the 3rd tertile with Lp-PLA2 values > 138 μg/L, in the 2nd tertile with Lp-PLA2 values between 101 and 138 μg/L and in the 1st tertile (Lp-PLA2 values 138 μg/L negatively correlated to FMD [b = − 0.45 (95% CI: − 0.79 – -0.11), P = 0.01] and AIx values [b = 1.81 (95% CI: 0.57–3.05), P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1476-511X |
| Relation: |
https://doaj.org/toc/1476-511X |
| DOI: |
10.1186/s12944-021-01438-4 |
| Access URL: |
https://doaj.org/article/c322aeb7e8fd408892f8686cc2194be5 |
| Accession Number: |
edsdoj.322aeb7e8fd408892f8686cc2194be5 |
| Database: |
Directory of Open Access Journals |
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