Academic Journal
Acute aflatoxin B1-induced hepatic and cardiac oxidative damage in rats: Ameliorative effects of morin
| Title: | Acute aflatoxin B1-induced hepatic and cardiac oxidative damage in rats: Ameliorative effects of morin |
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| Authors: | Ahmed E. Altyar, Osama A. Kensara, Amany A. Sayed, Lotfi Aleya, Mikhlid H. Almutairi, Mohamed Sayed Zaazouee, Alaa Ahmed Elshanbary, Fatma M. El-Demerdash, Mohamed M. Abdel-Daim |
| Source: | Heliyon, Vol 9, Iss 11, Pp e21837- (2023) |
| Publisher Information: | Elsevier, 2023. |
| Publication Year: | 2023 |
| Collection: | LCC:Science (General) LCC:Social sciences (General) |
| Subject Terms: | Mycotoxin, Flavonoids, Morin, Oxidative stress, Inflammation, Liver, Science (General), Q1-390, Social sciences (General), H1-99 |
| More Details: | Aflatoxins (AFs) are secondary metabolites produced by the fungus Aspergillus flavus, of which Aflatoxin-B1 (AFB1) appears to be the most cancerogenic and of the highest toxicity. AFB1 causes serious effects on several organs including the liver. Morin is a flavonol that exists in many fruits and plants and has diverse biological properties including anticancer, anti-atherosclerotic, antioxidant, anti-inflammatory, immunomodulatory, and multi-organ protective activities. The present study aims to evaluate the potential protective effects of morin against acute AFB1-induced hepatic and cardiac toxicity in rats. Forty rats were divided into five groups (n = 8) as follows: control received the vehicle, morin was orally administered 30/mg/kg body weight (MRN30), the AFB1 was administered orally at a dose of 2.5 mg/kg, twice on days 12 and 14 of the experiment for the 3rd, 4th, and 5th groups., AFB1-MRN15 was orally given morin at a dose of 15 mg/kg body weight, and AFB1-MRN30 orally received morin at 30 mg/kg body weight. The results indicated a significant decrease in serum AST, ALP, LDH, GGT, CK, CK-MB, 8-OHdG, IL-1β, IL-6, TNF-a levels in MRN30 compared to AFB1, and AFB1-MRN15 groups. However, the results indicated non-significant differences in the serum levels between MRN30, control, and AFB1-MRN30 groups. Meanwhile, regarding the hepatic and cardiac parameters, there were significant differences in the levels of MDA, NO, GSH, GSH-Px, SOD, and CAT in MRN30 compared to AFB1, and AFB1-MRN15 groups, overall implying the protective effects of morin. To conclude, morin at a dose of 30 mg/kg b. wt. showed significant enhancements in acute AFB1-induced hepatic and cardiac toxicity in rats, which could play a role in limiting the public health hazards of AFs. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2405-8440 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S240584402309045X; https://doaj.org/toc/2405-8440 |
| DOI: | 10.1016/j.heliyon.2023.e21837 |
| Access URL: | https://doaj.org/article/31abb0046f50431fa6db413ce5010f15 |
| Accession Number: | edsdoj.31abb0046f50431fa6db413ce5010f15 |
| Database: | Directory of Open Access Journals |
| ISSN: | 24058440 |
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| DOI: | 10.1016/j.heliyon.2023.e21837 |
| Published in: | Heliyon |
| Language: | English |