Extracellular vesicle-based therapeutics: natural versus engineered targeting and trafficking

Bibliographic Details
Title:	Extracellular vesicle-based therapeutics: natural versus engineered targeting and trafficking
Authors:	Daniel E. Murphy, Olivier G. de Jong, Maarten Brouwer, Matthew J. Wood, Grégory Lavieu, Raymond M. Schiffelers, Pieter Vader
Source:	Experimental and Molecular Medicine, Vol 51, Iss 3, Pp 1-12 (2019)
Publisher Information:	Nature Publishing Group, 2019.
Publication Year:	2019
Collection:	LCC:Medicine LCC:Biochemistry
Subject Terms:	Medicine, Biochemistry, QD415-436
More Details:	Therapeutics: Helping vesicles to deliver drugs inside cells An increased understanding of how extracellular vesicles (EVs) enter cells and deliver molecules will enable promising new therapies, according to researchers in the Netherlands, UK and France. EVs are liquid-filled sacs secreted by cells that transport proteins, lipids and RNA between cells, and therefore have potential for delivering drugs. Pieter Vader at UMC Utrecht and co-workers review recent research into EVs, focusing on how EVs are distributed around the body, and how they target and enter cells. However, there is little known about EV biology once they are inside cells, and it is likely that many EVs simply degrade without delivering their cargo. Further research in this area could help identify features that improve cargo escape from EVs, thus ensuring that future therapies can be effective.
Document Type:	article
File Description:	electronic resource
Language:	English
ISSN:	1226-3613 2092-6413
Relation:	https://doaj.org/toc/1226-3613; https://doaj.org/toc/2092-6413
DOI:	10.1038/s12276-019-0223-5
Access URL:	https://doaj.org/article/316df075eed04434ba364fbd33b3895c
Accession Number:	edsdoj.316df075eed04434ba364fbd33b3895c
Database:	Directory of Open Access Journals

More Details
ISSN:	12263613 20926413
DOI:	10.1038/s12276-019-0223-5
Published in:	Experimental and Molecular Medicine
Language:	English