Academic Journal
View in EDS
Linked Full Text

Antivirulence Activity of the Human Gut Metabolome

Bibliographic Details
Title: Antivirulence Activity of the Human Gut Metabolome
Authors: L. Caetano M. Antunes, Julie A. K. McDonald, Kathleen Schroeter, Christian Carlucci, Rosana B. R. Ferreira, Melody Wang, Sophie Yurist-Doutsch, Gill Hira, Kevan Jacobson, Julian Davies, Emma Allen-Vercoe, B. Brett Finlay
Source: mBio, Vol 5, Iss 4 (2014)
Publisher Information: American Society for Microbiology, 2014.
Publication Year: 2014
Collection: LCC:Microbiology
Subject Terms: Microbiology, QR1-502
More Details: ABSTRACT The mammalian gut contains a complex assembly of commensal microbes termed microbiota. Although much has been learned about the role of these microbes in health, the mechanisms underlying these functions are ill defined. We have recently shown that the mammalian gut contains thousands of small molecules, most of which are currently unidentified. Therefore, we hypothesized that these molecules function as chemical cues used by hosts and microbes during their interactions in health and disease. Thus, a search was initiated to identify molecules produced by the microbiota that are sensed by pathogens. We found that a secreted molecule produced by clostridia acts as a strong repressor of Salmonella virulence, obliterating expression of the Salmonella pathogenicity island 1 as well as host cell invasion. It has been known for decades that the microbiota protects its hosts from invading pathogens, and these data suggest that chemical sensing may be involved in this phenomenon. Further investigations should reveal the exact biological role of this molecule as well as its therapeutic potential. IMPORTANCE Microbes can communicate through the production and sensing of small molecules. Within the complex ecosystem formed by commensal microbes living in and on the human body, it is likely that these molecular messages are used extensively during the interactions between different microbial species as well as with host cells. Deciphering such a molecular dialect will be fundamental to our understanding of host-microbe interactions in health and disease and may prove useful for the design of new therapeutic strategies that target these mechanisms of communication.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2150-7511
Relation: https://doaj.org/toc/2150-7511
DOI: 10.1128/mBio.01183-14
Access URL: https://doaj.org/article/31426e0979bd4386b6d2703131aafb7d
Accession Number: edsdoj.31426e0979bd4386b6d2703131aafb7d
Database: Directory of Open Access Journals
FullText Links:
  – Type: other
    Url: https://resolver.ebsco.com:443/public/rma-ftfapi/ejs/direct?AccessToken=48C0AB74C82094890CDF&Show=Object
Text:
  Availability: 0
CustomLinks:
  – Url: https://resolver.ebsco.com/c/xy5jbn/result?sid=EBSCO:edsdoj&genre=article&issn=21507511&ISBN=&volume=5&issue=4&date=20140801&spage=&pages=&title=mBio&atitle=Antivirulence%20Activity%20of%20the%20Human%20Gut%20Metabolome&aulast=L.%20Caetano%20M.%20Antunes&id=DOI:10.1128/mBio.01183-14
    Name: Full Text Finder (for New FTF UI) (s8985755)
    Category: fullText
    Text: Find It @ SCU Libraries
    MouseOverText: Find It @ SCU Libraries
  – Url: https://doaj.org/article/31426e0979bd4386b6d2703131aafb7d
    Name: EDS - DOAJ (s8985755)
    Category: fullText
    Text: View record from DOAJ
    MouseOverText: View record from DOAJ
Header DbId: edsdoj
DbLabel: Directory of Open Access Journals
An: edsdoj.31426e0979bd4386b6d2703131aafb7d
RelevancyScore: 855
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 854.611389160156
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Antivirulence Activity of the Human Gut Metabolome
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22L%2E+Caetano+M%2E+Antunes%22">L. Caetano M. Antunes</searchLink><br /><searchLink fieldCode="AR" term="%22Julie+A%2E+K%2E+McDonald%22">Julie A. K. McDonald</searchLink><br /><searchLink fieldCode="AR" term="%22Kathleen+Schroeter%22">Kathleen Schroeter</searchLink><br /><searchLink fieldCode="AR" term="%22Christian+Carlucci%22">Christian Carlucci</searchLink><br /><searchLink fieldCode="AR" term="%22Rosana+B%2E+R%2E+Ferreira%22">Rosana B. R. Ferreira</searchLink><br /><searchLink fieldCode="AR" term="%22Melody+Wang%22">Melody Wang</searchLink><br /><searchLink fieldCode="AR" term="%22Sophie+Yurist-Doutsch%22">Sophie Yurist-Doutsch</searchLink><br /><searchLink fieldCode="AR" term="%22Gill+Hira%22">Gill Hira</searchLink><br /><searchLink fieldCode="AR" term="%22Kevan+Jacobson%22">Kevan Jacobson</searchLink><br /><searchLink fieldCode="AR" term="%22Julian+Davies%22">Julian Davies</searchLink><br /><searchLink fieldCode="AR" term="%22Emma+Allen-Vercoe%22">Emma Allen-Vercoe</searchLink><br /><searchLink fieldCode="AR" term="%22B%2E+Brett+Finlay%22">B. Brett Finlay</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: mBio, Vol 5, Iss 4 (2014)
– Name: Publisher
  Label: Publisher Information
  Group: PubInfo
  Data: American Society for Microbiology, 2014.
– Name: DatePubCY
  Label: Publication Year
  Group: Date
  Data: 2014
– Name: Subset
  Label: Collection
  Group: HoldingsInfo
  Data: LCC:Microbiology
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Microbiology%22">Microbiology</searchLink><br /><searchLink fieldCode="DE" term="%22QR1-502%22">QR1-502</searchLink>
– Name: Abstract
  Label: Description
  Group: Ab
  Data: ABSTRACT The mammalian gut contains a complex assembly of commensal microbes termed microbiota. Although much has been learned about the role of these microbes in health, the mechanisms underlying these functions are ill defined. We have recently shown that the mammalian gut contains thousands of small molecules, most of which are currently unidentified. Therefore, we hypothesized that these molecules function as chemical cues used by hosts and microbes during their interactions in health and disease. Thus, a search was initiated to identify molecules produced by the microbiota that are sensed by pathogens. We found that a secreted molecule produced by clostridia acts as a strong repressor of Salmonella virulence, obliterating expression of the Salmonella pathogenicity island 1 as well as host cell invasion. It has been known for decades that the microbiota protects its hosts from invading pathogens, and these data suggest that chemical sensing may be involved in this phenomenon. Further investigations should reveal the exact biological role of this molecule as well as its therapeutic potential. IMPORTANCE Microbes can communicate through the production and sensing of small molecules. Within the complex ecosystem formed by commensal microbes living in and on the human body, it is likely that these molecular messages are used extensively during the interactions between different microbial species as well as with host cells. Deciphering such a molecular dialect will be fundamental to our understanding of host-microbe interactions in health and disease and may prove useful for the design of new therapeutic strategies that target these mechanisms of communication.
– Name: TypeDocument
  Label: Document Type
  Group: TypDoc
  Data: article
– Name: Format
  Label: File Description
  Group: SrcInfo
  Data: electronic resource
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: ISSN
  Label: ISSN
  Group: ISSN
  Data: 2150-7511
– Name: NoteTitleSource
  Label: Relation
  Group: SrcInfo
  Data: https://doaj.org/toc/2150-7511
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.1128/mBio.01183-14
– Name: URL
  Label: Access URL
  Group: URL
  Data: <link linkTarget="URL" linkTerm="https://doaj.org/article/31426e0979bd4386b6d2703131aafb7d" linkWindow="_blank">https://doaj.org/article/31426e0979bd4386b6d2703131aafb7d</link>
– Name: AN
  Label: Accession Number
  Group: ID
  Data: edsdoj.31426e0979bd4386b6d2703131aafb7d
PLink https://login.libproxy.scu.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsdoj&AN=edsdoj.31426e0979bd4386b6d2703131aafb7d
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1128/mBio.01183-14
    Languages:
      – Text: English
    Subjects:
      – SubjectFull: Microbiology
        Type: general
      – SubjectFull: QR1-502
        Type: general
    Titles:
      – TitleFull: Antivirulence Activity of the Human Gut Metabolome
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: L. Caetano M. Antunes
      – PersonEntity:
          Name:
            NameFull: Julie A. K. McDonald
      – PersonEntity:
          Name:
            NameFull: Kathleen Schroeter
      – PersonEntity:
          Name:
            NameFull: Christian Carlucci
      – PersonEntity:
          Name:
            NameFull: Rosana B. R. Ferreira
      – PersonEntity:
          Name:
            NameFull: Melody Wang
      – PersonEntity:
          Name:
            NameFull: Sophie Yurist-Doutsch
      – PersonEntity:
          Name:
            NameFull: Gill Hira
      – PersonEntity:
          Name:
            NameFull: Kevan Jacobson
      – PersonEntity:
          Name:
            NameFull: Julian Davies
      – PersonEntity:
          Name:
            NameFull: Emma Allen-Vercoe
      – PersonEntity:
          Name:
            NameFull: B. Brett Finlay
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 08
              Type: published
              Y: 2014
          Identifiers:
            – Type: issn-print
              Value: 21507511
          Numbering:
            – Type: volume
              Value: 5
            – Type: issue
              Value: 4
          Titles:
            – TitleFull: mBio
              Type: main
ResultId 1