Bibliographic Details
| Title: |
Sarcoidosis in the setting of combination ipilimumab and nivolumab immunotherapy: a case report & review of the literature |
| Authors: |
Craig L. Slingluff, Paul R. Kunk, Joshua E. Reuss, Anne M. Stowman, Alejandro A. Gru, Elizabeth M. Gaughan |
| Source: |
Journal for ImmunoTherapy of Cancer, Vol 4, Iss 1 (2016) |
| Publisher Information: |
BMJ Publishing Group, 2016. |
| Publication Year: |
2016 |
| Collection: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: |
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: |
Background We report a case of sarcoidosis in a patient with metastatic melanoma managed with combination ipilimumab/nivolumab. Sarcoid development has been linked with single agent immunotherapy but, to our knowledge, it has not been reported with combination ipilimumab/nivolumab treatment. This case raises unique management challenges for both the melanoma and the immunotherapy-related toxicity.Case presentation A 46 year old Caucasian female with M1c-metastatic melanoma was managed with ipilimumab/nivolumab combination. Patient experienced response in baseline lesions but developed new clinical and radiographic findings. Biopsy of new lesions at two different sites both demonstrated tumefactive sarcoidosis. Staining of the biopsy tissue for PD-L1 expression demonstrated strong PD-L1 staining of the histiocytes and lymphocytes within the granulomas. Monotherapy nivolumab was continued without progression of sarcoid findings or clinical deterioration.Conclusions Tissue biopsy for evaluation of new lesions on immunotherapy is an important step to help guide decision making, as non-melanoma lesions can mimic disease progression. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2051-1426 |
| Relation: |
https://jitc.bmj.com/content/4/1/94.full; https://doaj.org/toc/2051-1426 |
| DOI: |
10.1186/s40425-016-0199-9 |
| Access URL: |
https://doaj.org/article/3124a1d3ca5e4c1598b68d90fc08a3a5 |
| Accession Number: |
edsdoj.3124a1d3ca5e4c1598b68d90fc08a3a5 |
| Database: |
Directory of Open Access Journals |
