Training Does Not Alter Muscle Ceramide and Diacylglycerol in Offsprings of Type 2 Diabetic Patients Despite Improved Insulin Sensitivity

Bibliographic Details
Title:	Training Does Not Alter Muscle Ceramide and Diacylglycerol in Offsprings of Type 2 Diabetic Patients Despite Improved Insulin Sensitivity
Authors:	Ditte Søgaard, Torben Østergård, Agnieszka U. Blachnio-Zabielska, Marcin Baranowski, Andreas Hansen Vigelsø, Jesper Løvind Andersen, Flemming Dela, Jørn Wulff Helge
Source:	Journal of Diabetes Research, Vol 2016 (2016)
Publisher Information:	Hindawi Limited, 2016.
Publication Year:	2016
Collection:	LCC:Diseases of the endocrine glands. Clinical endocrinology
Subject Terms:	Diseases of the endocrine glands. Clinical endocrinology, RC648-665
More Details:	Ceramide and diacylglycerol (DAG) may be involved in the early phase of insulin resistance but data are inconsistent in man. We evaluated if an increase in insulin sensitivity after endurance training was accompanied by changes in these lipids in skeletal muscle. Nineteen first-degree type 2 diabetes Offsprings (Offsprings) (age: 33.1±1.4 yrs; BMI: 26.4±0.4 kg/m2) and sixteen matched Controls (age: 31.3±1.5 yrs; BMI: 25.3±0.7 kg/m2) performed 10 weeks of endurance training three times a week at 70% of VO2max on a bicycle ergometer. Before and after the intervention a hyperinsulinemic-euglycemic clamp and VO2max test were performed and muscle biopsies obtained. Insulin sensitivity was significantly lower in Offsprings compared to control subjects (p
Document Type:	article
File Description:	electronic resource
Language:	English
ISSN:	2314-6745 2314-6753
Relation:	https://doaj.org/toc/2314-6745; https://doaj.org/toc/2314-6753
DOI:	10.1155/2016/2372741
Access URL:	https://doaj.org/article/30ec84d264644612b052ed2085afb70f
Accession Number:	edsdoj.30ec84d264644612b052ed2085afb70f
Database:	Directory of Open Access Journals

More Details
ISSN:	23146745 23146753
DOI:	10.1155/2016/2372741
Published in:	Journal of Diabetes Research
Language:	English