The behavior of Troponin I and CKMB mass in children who underwent surgical correction of congenital heart malformations Comportamento da troponina I e CK-MB massa em crianças submetidas a correção cirúrgica das cardiopatias congênitas
| Title: | The behavior of Troponin I and CKMB mass in children who underwent surgical correction of congenital heart malformations Comportamento da troponina I e CK-MB massa em crianças submetidas a correção cirúrgica das cardiopatias congênitas |
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| Authors: | Pedro Rafael Salerno, Fabio Biscegli Jatene, Patrícia Elias Figueiredo, Ieda Jatene Bosisio, Marcelo Biscegli Jatene, Magaly Arraes dos Santos, Luís Carlos Bento de Souza, Adib Domingos Jatene |
| Source: | Brazilian Journal of Cardiovascular Surgery, Vol 18, Iss 3, Pp 235-241 (2003) |
| Publisher Information: | Sociedade Brasileira de Cirurgia Cardiovascular, 2003. |
| Publication Year: | 2003 |
| Collection: | LCC:Surgery LCC:Diseases of the circulatory (Cardiovascular) system |
| Subject Terms: | Troponina I, Creatina quinase, Cardiopatias congênitas, Sulfato de magnésio, Soluções cardioplégicas, Troponin I, Creatine kinase, Heart defects, congenital, Magnesium sulfate, Cardioplegic solutions, Surgery, RD1-811, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| More Details: | OBJECTIVE: To analyze the behavior of troponin (TROP I) and CKMB mass (CKMBm) in regards to the addition of magnesium in cardioplegic solutions; and also the influence of per-operative factors. METHOD: A total of 28 children with ages ranging from 3 to 108 months were studied. The mean weight was 11.8 kg. Eighteen were male. The patients were divided into two groups. Sixteen children in group I (GI) and 12 in group II (GII). The patients in GI received cold blood cardioplegic solution with magnesium (12 mEq/L) and potassium chloride (20 mEq/L) at 20 mL/kg. The patients in GII received the same solution without magnesium. Six blood samples were collected for serum analysis of the concentration of TROP I and CKMBm. The blood samples were collected before clamping the aorta and at 1, 6, 24, 48 and 72 hours after aorta clamping termination. RESULTS: There were no statistical differences in the TROP I and CKMBm levels between the two groups. Among the per-operative factors cyanosis influenced the TROP I and CKMBm levels. Additionally, the aorta clamping time influenced the TROP I levels. CONCLUSIONS: The addition of magnesium in the cardioplegic solution was not associated with different levels of TROP I and CKMBm. Cyanosis and aorta clamping time interfered with peak TROP I levels.OBJETIVO: Analisar o comportamento da troponina I (TROP I) e CKMB massa (CKMBm) conforme a adição ou não de magnésio (Mg) na cardioplegia e a influência dos fatores operatórios. MÉTODO: Foram estudadas 28 crianças com a idade de 3 a 108 meses, peso médio de 11,8 kg, sendo 18 do sexo masculino, divididas em dois grupos, 16 no grupo I (GI) e 12 no grupo II (GII). O GI recebeu solução cardioplégica sangüínea fria com Mg 12 mEq/L e cloreto de potássio 20 mEq/L na dose de 20 mL/kg. O GII recebeu a mesma solução sem o (Mg). Foram coletadas seis amostras de sangue para a dosagem sérica de TROP I e CKMBm: pré-pinçamento da aorta e com 1, 6, 24, 48 e 72 horas após o término do pinçamento da aorta. RESULTADOS: Os resultados demonstraram que não houve diferença estatisticamente significante nos níveis TROP I e CKMBm, entre GI e GII. Dentre os fatores operatórios, a cianose influenciou nos níveis de TROP I e CKMBm, enquanto que o tempo de pinçamento da aorta (TPA) influenciou nos níveis de TROP I. CONCLUSÕES: A adição de Mg na solução cardioplégica não esteve associada com níveis diferentes de TROP I e CKMBm. A cianose e o TPA interferiram no pico de TROP I. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 0102-7638 1678-9741 |
| Relation: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382003000300008; https://doaj.org/toc/0102-7638; https://doaj.org/toc/1678-9741 |
| DOI: | 10.1590/S0102-76382003000300008 |
| Access URL: | https://doaj.org/article/d30d1958e8924fe9a1312d83df6686ae |
| Accession Number: | edsdoj.30d1958e8924fe9a1312d83df6686ae |
| Database: | Directory of Open Access Journals |
| ISSN: | 01027638 16789741 |
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| DOI: | 10.1590/S0102-76382003000300008 |
| Published in: | Brazilian Journal of Cardiovascular Surgery |
| Language: | English |