| Title: |
Peptides from hydrolysate of lantern fish (Benthosema pterotum) proved neuroprotective in vitro and in vivo |
| Authors: |
Huey-Jine Chai, Chang-Jer Wu, Shu-Han Yang, Tsung-Lin Li, Bonnie Sun Pan |
| Source: |
Journal of Functional Foods, Vol 24, Iss , Pp 438-449 (2016) |
| Publisher Information: |
Elsevier, 2016. |
| Publication Year: |
2016 |
| Collection: |
LCC:Nutrition. Foods and food supply |
| Subject Terms: |
Benthosema pterotum, Protein hydrolysate, neuroprotective, Morris water-maze test, Brain-derived neurotrophy factor, Intracellular antioxidant, Anti-ageing, Nutrition. Foods and food supply, TX341-641 |
| More Details: |
Benthosema pterotum is an underutilized deep-sea by-catch fish. Its protein hydrolysate (BPH) showed antioxidative activity. The BPH consisting of 13.2 mg/g of active peptides, Phe-Tyr-Tyr and Asp-Trp, significantly reduced H2O2-induced reactive oxygen species (ROS) and apoptotic cell death in human neuroblastoma SH-SY5Y cells through activation of intracellular antioxidant defence system. In Morris water-maze test, BPH was able to ameliorate memory and learning deficiency of D-galactose (D-gal)-induced neurodegenerative/ageing ICR mice. BPH-fed mice showed significantly lower levels of both D-gal-induced thiobarbituric acid reactive substances (TBARS) and endothelial nitric oxide synthase (eNOS), but higher levels of glucose-6-phosphate dehydrogenase (G6PDH) and brain-derived neurotrophy factor (BDNF) in brain of ageing mice in comparison to the control. In light of these results, BPH may be considered as a novel nutraceutical for easing the ageing and/or age-related neurodegenerative diseases. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1756-4646 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S1756464616300639; https://doaj.org/toc/1756-4646 |
| DOI: |
10.1016/j.jff.2016.04.009 |
| Access URL: |
https://doaj.org/article/30c8e7eca7eb4e9e9cc7d090fb0b814c |
| Accession Number: |
edsdoj.30c8e7eca7eb4e9e9cc7d090fb0b814c |
| Database: |
Directory of Open Access Journals |
