Obstetrical outcome and treatments in seronegative primary APS: data from European retrospective study
| Title: | Obstetrical outcome and treatments in seronegative primary APS: data from European retrospective study |
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| Authors: | Arsène Mekinian, Eric Hachulla, Olivier Fain, Marc Lambert, Claire de Moreuil, Yann Nguyen, Noemie Abisror, Luca Marozio, Enrique Esteve Valverde, Sebastian Udry, Daniel Enrique Pleguezuelo, Paul Billoir, Karoline Mayer-Pickel, Geoffrey Urbanski, Polona Zigon, Ariela Hoxha, Holy Bezanahary, Lionel Carbillon, Gilles Kayem, Marie Bornes, Cecile Yelnik, Cathererine Johanet, Pascale Nicaise-Roland, Valéry Salle, Omar Jose Latino, Chiara Benedetto, Marie Charlotte Bourrienne, Ygal Benhamou, Jaume Alijotas-Reig |
| Source: | RMD Open, Vol 6, Iss 2 (2020) |
| Publisher Information: | BMJ Publishing Group, 2020. |
| Publication Year: | 2020 |
| Collection: | LCC:Medicine |
| Subject Terms: | Medicine |
| More Details: | Objective To compare characteristics, pregnancies and treatments during pregnancies of seronegative and seropositive antiphospholipid syndrome (APS), to analyse factors associated with obstetrical outcome.Patients and methods Inclusion criteria were: (1) thrombotic and/or obstetrical APS (Sydney criteria); (2) absence of conventional antiphospholipid antibodies (APL); (3) at least one persistent non-conventional APL among IgA anticardiolipin antibodies, IgA anti-B2GPI, anti-vimentin G/M, anti-annexin V G/M, anti-phosphatidylethanolamine G/M and anti-phosphatidylserine/prothrombin G/M antibodies. The exclusion criteria were: (1) systemic lupus erythematosus ( SLE) or SLE-like disease; and (2) other connective tissue disease.Results A total of 187 women (mean 33±5 years) with seronegative APS were included from 14 centres in Austria, Spain, Italy, Slovenia and France and compared with 285 patients with seropositive APS. Seronegative APS has more obstetrical rather than thrombotic phenotypes, with only 6% of venous thrombosis in comparison to seropositive APS. Cumulative incidence of adverse obstetrical events was similar in seronegative and seropositive APS patients, although higher rates of intrauterine deaths (15% vs 5%; p=0.03), of preeclampsia (7% vs 16%, p=0.048) and lower live birth term (36±3 vs 38±3 weeks of gestation; p=0.04) were noted in seropositive APS. The cumulative incidence of adverse obstetrical events was significantly improved in treated versus untreated seronegative APS (log rank |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2020-0013 2056-5933 |
| Relation: | https://rmdopen.bmj.com/content/6/2/0.full; https://doaj.org/toc/2056-5933 |
| DOI: | 10.1136/rmdopen-2020-001340 |
| Access URL: | https://doaj.org/article/309364fd4f1f4c8da70735b3aeedecd4 |
| Accession Number: | edsdoj.309364fd4f1f4c8da70735b3aeedecd4 |
| Database: | Directory of Open Access Journals |
| ISSN: | 20200013 20565933 |
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| DOI: | 10.1136/rmdopen-2020-001340 |
| Published in: | RMD Open |
| Language: | English |