Bibliographic Details
| Title: |
Randomized, Double-Blind, Placebo-Controlled Trial of a Throat Spray with Selected Lactobacilli in COVID-19 Outpatients |
| Authors: |
Ilke De Boeck, Eline Cauwenberghs, Irina Spacova, Thies Gehrmann, Tom Eilers, Lize Delanghe, Stijn Wittouck, Peter A. Bron, Tim Henkens, Imane Gamgami, Alix Simons, Ingmar Claes, Joachim Mariën, Kevin K. Ariën, Diana Bakokimi, Katherine Loens, Kevin Jacobs, Margareta Ieven, Patricia Bruijning-Verhagen, Peter Delputte, Samuel Coenen, Veronique Verhoeven, Sarah Lebeer |
| Source: |
Microbiology Spectrum, Vol 10, Iss 5 (2022) |
| Publisher Information: |
American Society for Microbiology, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Microbiology |
| Subject Terms: |
COVID-19, lactobacilli, microbiome, throat spray, Microbiology, QR1-502 |
| More Details: |
ABSTRACT Primary care urgently needs treatments for coronavirus disease 2019 (COVID-19) patients because current options are limited, while these patients who do not require hospitalization encompass more than 90% of the people infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we evaluated a throat spray containing three Lactobacillaceae strains with broad antiviral properties in a randomized, double-blind, placebo-controlled trial. Before the availability of vaccines, 78 eligible COVID-19 patients were randomized to verum (n = 41) and placebo (n = 37) within 96 h of a positive PCR-based SARS-CoV-2 diagnosis, and a per-protocol analysis was performed. Symptoms and severity were reported daily via an online diary. Combined nose-throat swabs and dried blood spots were collected at regular time points in the study for microbiome, viral load, and antibody analyses. The daily reported symptoms were highly variable, with no added benefit for symptom resolution in the verum group. However, based on 16S V4 amplicon sequencing, the acute symptom score (fever, diarrhea, chills, and muscle pain) was significantly negatively associated with the relative abundance of amplicon sequence variants (ASVs) that included the applied lactobacilli (P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2165-0497 |
| Relation: |
https://doaj.org/toc/2165-0497 |
| DOI: |
10.1128/spectrum.01682-22 |
| Access URL: |
https://doaj.org/article/3090e3a21cdd4120a38d44cf9c4caa1b |
| Accession Number: |
edsdoj.3090e3a21cdd4120a38d44cf9c4caa1b |
| Database: |
Directory of Open Access Journals |
