Bibliographic Details
| Title: |
Dynamic Perturbations of CD4 and CD8 T Cell Receptor Repertoires in Chronic Hepatitis B Patients upon Oral Antiviral Therapy |
| Authors: |
Ying Xu, Yu Liu, Miaoxian Zhao, Yunqing Chen, Cantao Xie, Mingxing Gong, Haohui Deng, Xueying Li, Jian Sun, Jinlin Hou, Hongkai Wu, Zhanhui Wang |
| Source: |
Frontiers in Immunology, Vol 8 (2017) |
| Publisher Information: |
Frontiers Media S.A., 2017. |
| Publication Year: |
2017 |
| Collection: |
LCC:Immunologic diseases. Allergy |
| Subject Terms: |
high-throughput sequencing, chronic hepatitis B infection, nucleos(t)ide analogs, hepatitis B e antigen seroconversion, T cell receptor, Immunologic diseases. Allergy, RC581-607 |
| More Details: |
Long-term treatment with nucleos(t)ide analogs (NUCs) can improve the antiviral T cell response in chronic hepatitis B (CHB) patients. Whether and to what extent the T cell response is improved by NUCs in the early stage leading to hepatitis B e antigen (HBeAg) seroconversion remain to be clarified. A total of 22 CHB patients undergoing 2-year telbivudine-based therapy were enrolled, including 10 exhibiting a complete response (CR) and 12 exhibiting a non-complete response (NCR) according to HBeAg seroconversion at week 52. Peripheral CD4+ and CD8+ T cells were sorted at baseline, weeks 12, and 24. The T cell receptor β chain (TCRβ) complementarity-determining region 3 was analyzed by unbiased high-throughput sequencing. Compared with NCR group, patients in CR group had a much lower percentage of persistent clonotypes (P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1664-3224 |
| Relation: |
http://journal.frontiersin.org/article/10.3389/fimmu.2017.01142/full; https://doaj.org/toc/1664-3224 |
| DOI: |
10.3389/fimmu.2017.01142 |
| Access URL: |
https://doaj.org/article/3080f6c3b28048f8b5e628a462a8ff9a |
| Accession Number: |
edsdoj.3080f6c3b28048f8b5e628a462a8ff9a |
| Database: |
Directory of Open Access Journals |
