The cerebellum is involved in processing of predictions and prediction errors in a fear conditioning paradigm
| Title: | The cerebellum is involved in processing of predictions and prediction errors in a fear conditioning paradigm |
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| Authors: | Thomas Michael Ernst, Anna Evelina Brol, Marcel Gratz, Christoph Ritter, Ulrike Bingel, Marc Schlamann, Stefan Maderwald, Harald H Quick, Christian Josef Merz, Dagmar Timmann |
| Source: | eLife, Vol 8 (2019) |
| Publisher Information: | eLife Sciences Publications Ltd, 2019. |
| Publication Year: | 2019 |
| Collection: | LCC:Medicine LCC:Science LCC:Biology (General) |
| Subject Terms: | emotions, extinction, fear, vermis, cerebellar hemisphere, aversive conditioning, Medicine, Science, Biology (General), QH301-705.5 |
| More Details: | Prediction errors are thought to drive associative fear learning. Surprisingly little is known about the possible contribution of the cerebellum. To address this question, healthy participants underwent a differential fear conditioning paradigm during 7T magnetic resonance imaging. An event-related design allowed us to separate cerebellar fMRI signals related to the visual conditioned stimulus (CS) from signals related to the subsequent unconditioned stimulus (US; an aversive electric shock). We found significant activation of cerebellar lobules Crus I and VI bilaterally related to the CS+ compared to the CS-. Most importantly, significant activation of lobules Crus I and VI was also present during the unexpected omission of the US in unreinforced CS+ acquisition trials. This activation disappeared during extinction when US omission became expected. These findings provide evidence that the cerebellum has to be added to the neural network processing predictions and prediction errors in the emotional domain. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2050-084X |
| Relation: | https://elifesciences.org/articles/46831; https://doaj.org/toc/2050-084X |
| DOI: | 10.7554/eLife.46831 |
| Access URL: | https://doaj.org/article/30761d716c7145b3aa0e53a6a95f0c35 |
| Accession Number: | edsdoj.30761d716c7145b3aa0e53a6a95f0c35 |
| Database: | Directory of Open Access Journals |
| ISSN: | 2050084X |
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| DOI: | 10.7554/eLife.46831 |
| Published in: | eLife |
| Language: | English |