A single-center’s uric acid profile in girls with Turner syndrome
| Title: | A single-center’s uric acid profile in girls with Turner syndrome |
|---|---|
| Authors: | Song Guo, Qiuli Chen, Jun Zhang, Meihua Wei, Rujiang Zheng, Bing Wang, Yanhong Li, Huamei Ma, Xiaoyun Jiang |
| Source: | Frontiers in Endocrinology, Vol 15 (2024) |
| Publisher Information: | Frontiers Media S.A., 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Diseases of the endocrine glands. Clinical endocrinology |
| Subject Terms: | Turner syndrome, serum uric acid, lipids, insulin resistance, stanozolol, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| More Details: | BackgroundMetabolic disorders are common in individuals with Turner syndrome (TS). Hyperuricemia is associated with metabolic syndrome. This study investigated the serum uric acid (SUA) profile in patients with TS.MethodsA retrospective observational study was conducted with 145 patients with TS. A total of 72 normal girls were in the control group from 2015 to 2024: 86 TS patients were treated with growth hormone (GH), 80 with stanozolol, and 52 with estrogen.ResultsHyperuricemia was present in 33.1% (47/145) of patients with untreated TS and in 16.67% (12/72) of the controls (P < 0.001). Multivariable linear regression analysis showed that BMISDS, fasting serum glucose, and eGFR explained 34.4% (model R2 = 0.344) of the total variation in SUA in the untreated TS group. SUA and SUASDS (SUA standard deviation score) levels generally showed a slow rising tendency with age. SUA increased significantly in the first year of stanozolol initiation (P = 0.032), while adding estrogen and stanozolol improved the lipid profile during the whole assessment period.ConclusionGirls with TS showed a slow rising tendency in SUA and SUASDS with age and had higher SUA and SUASDS levels and incidence of hyperuricemia compared to their healthy female peers. The independent risk factors for hyperuricemia in pediatric patients with TS were BMISDS, HOMA-IR, glucose, and eGFR. The incidence of hyperuricemia increased in the first year of stanozolol treatment. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1664-2392 30437490 |
| Relation: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1442166/full; https://doaj.org/toc/1664-2392 |
| DOI: | 10.3389/fendo.2024.1442166 |
| Access URL: | https://doaj.org/article/c306cf167f304374906a59014956412d |
| Accession Number: | edsdoj.306cf167f304374906a59014956412d |
| Database: | Directory of Open Access Journals |
| ISSN: | 16642392 30437490 |
|---|---|
| DOI: | 10.3389/fendo.2024.1442166 |
| Published in: | Frontiers in Endocrinology |
| Language: | English |