Voriconazole and posaconazole therapeutic drug monitoring: a retrospective study
| Title: | Voriconazole and posaconazole therapeutic drug monitoring: a retrospective study |
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| Authors: | Whitley M. Yi, Kelly E. Schoeppler, Jaclyn Jaeger, Scott W. Mueller, Robert MacLaren, Douglas N. Fish, Tyree H. Kiser |
| Source: | Annals of Clinical Microbiology and Antimicrobials, Vol 16, Iss 1, Pp 1-14 (2017) |
| Publisher Information: | BMC, 2017. |
| Publication Year: | 2017 |
| Collection: | LCC:Therapeutics. Pharmacology LCC:Infectious and parasitic diseases LCC:Microbiology |
| Subject Terms: | Voriconazole, Posaconazole, Therapeutic drug monitoring, Invasive fungal disease, Therapeutics. Pharmacology, RM1-950, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502 |
| More Details: | Abstract Background Therapeutic drug monitoring (TDM) aims to minimize the clinical impact of posaconazole and voriconazole pharmacokinetic variability. However, its benefits on clinical outcomes are still being defined. Additionally, TDM data are limited for posaconazole IV and delayed-release tablet formulations among specific patient populations, including critically ill. The aim of this study was to determine the percentage of therapeutic posaconazole and voriconazole drug levels across all formulations in a real-world clinical setting and elucidate factors affecting attainment of target concentrations. Methods This study was a retrospective cohort study conducted at the University of Colorado Hospital between September 2006 and June 2015 that evaluated patients who received posaconazole or voriconazole TDM as part of routine care. Results Voriconazole (n = 250) and posaconazole (n = 100) levels were analyzed from 151 patients. Of these, 54% of voriconazole and 69% of posaconazole levels were therapeutic. For posaconazole, 14/38 (37%), 28/29 (97%) and 27/33 (82%) levels were therapeutic for the oral suspension, IV, and delayed-release tablet, respectively. Intravenous and delayed-release tablet posaconazole were 20 fold (p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1476-0711 |
| Relation: | http://link.springer.com/article/10.1186/s12941-017-0235-8; https://doaj.org/toc/1476-0711 |
| DOI: | 10.1186/s12941-017-0235-8 |
| Access URL: | https://doaj.org/article/e30344579ca149a49c0e111866248e61 |
| Accession Number: | edsdoj.30344579ca149a49c0e111866248e61 |
| Database: | Directory of Open Access Journals |
| ISSN: | 14760711 |
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| DOI: | 10.1186/s12941-017-0235-8 |
| Published in: | Annals of Clinical Microbiology and Antimicrobials |
| Language: | English |