Academic Journal
HIF-1α signaling: Essential roles in tumorigenesis and implications in targeted therapies
| Title: | HIF-1α signaling: Essential roles in tumorigenesis and implications in targeted therapies |
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| Authors: | Yan Zhao, Cheng Xing, Yating Deng, Can Ye, Hongling Peng |
| Source: | Genes and Diseases, Vol 11, Iss 1, Pp 234-251 (2024) |
| Publisher Information: | KeAi Communications Co., Ltd., 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Medicine (General) LCC:Genetics |
| Subject Terms: | Angiogenesis, Hematological malignancies, Hypoxia-inducible factor-1 alpha (HIF-1α), Immune escape, Targeted therapy, Medicine (General), R5-920, Genetics, QH426-470 |
| More Details: | The hypoxic microenvironment is an essential characteristic of most malignant tumors. Notably, hypoxia-inducible factor-1 alpha (HIF-1α) is a key regulatory factor of cellular adaptation to hypoxia, and many critical pathways are correlated with the biological activity of organisms via HIF-1α. In the intra-tumoral hypoxic environment, HIF-1α is highly expressed and contributes to the malignant progression of tumors, which in turn results in a poor prognosis in patients. Recently, it has been indicated that HIF-1α involves in various critical processes of life events and tumor development via regulating the expression of HIF-1α target genes, such as cell proliferation and apoptosis, angiogenesis, glucose metabolism, immune response, therapeutic resistance, etc. Apart from solid tumors, accumulating evidence has revealed that HIF-1α is also closely associated with the development and progression of hematological malignancies, such as leukemia, lymphoma, and multiple myeloma. Targeted inhibition of HIF-1α can facilitate an increased sensitivity of patients with malignancies to relevant therapeutic agents. In the review, we elaborated on the basic structure and biological functions of HIF-1α and summarized their current role in various malignancies. It is expected that they will have future potential for targeted therapy. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2352-3042 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2352304223001058; https://doaj.org/toc/2352-3042 |
| DOI: | 10.1016/j.gendis.2023.02.039 |
| Access URL: | https://doaj.org/article/300424bef78f417d810da6b82f0ac9b6 |
| Accession Number: | edsdoj.300424bef78f417d810da6b82f0ac9b6 |
| Database: | Directory of Open Access Journals |
| ISSN: | 23523042 |
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| DOI: | 10.1016/j.gendis.2023.02.039 |
| Published in: | Genes and Diseases |
| Language: | English |