Bibliographic Details
| Title: |
Ultrasensitive Ti3C2Tx@Pt-Based Immunochromatography with Catalytic Amplification and a Dual Signal for the Detection of Chloramphenicol in Animal-Derived Foods |
| Authors: |
Mengfang Lin, Zhimin Gao, Zhenjie Qian, Youwen Deng, Yanhong Chen, Yu Wang, Xiangmei Li |
| Source: |
Foods, Vol 13, Iss 9, p 1416 (2024) |
| Publisher Information: |
MDPI AG, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Chemical technology |
| Subject Terms: |
Ti3C2Tx@Pt, catalytic amplification, chloramphenicol, immunochromatographic assay, MXene, Chemical technology, TP1-1185 |
| More Details: |
Herein, a catalytic amplification enhanced dual-signal immunochromatographic assay (ICA) based on Pt nanoparticles (Pt NPs) modified with Ti3C2Tx MXene (Ti3C2Tx@Pt) was first developed for chloramphenicol (CAP) in animal-derived foods. Due to the large specific surface area and abundant active sites of Ti3C2Tx@Pt, they can be loaded with hundreds of Pt NPs to enhance their catalytic activity, resulting in a significant increase in the detection sensitivity; the sensitivity was up to 50-fold more sensitive than the reported ICA for CAP. The LODs of the developed method for milk/chicken/fish were 0.01 μg/kg, the LOQs were 0.03 μg/kg and the recovery rates were 80.5–117.0%, 87.2–118.1% and 92.7–117.9%, with corresponding variations ranging from 3.1 to 9.6%, 6.0 to 12.7% and 6.0 to 13.6%, respectively. The linear range was 0.0125–1.0 μg/kg. The results of the LC-MS/MS confirmation test on 30 real samples had a good correlation with that of our established method (R2 > 0.98), indicating the practical reliability of the established method. The above results indicated that an ICA based on the Ti3C2Tx@Pt nanozyme has excellent potential as a food safety detection tool. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2304-8158 |
| Relation: |
https://www.mdpi.com/2304-8158/13/9/1416; https://doaj.org/toc/2304-8158 |
| DOI: |
10.3390/foods13091416 |
| Access URL: |
https://doaj.org/article/c2fd46867e444490a0207b2fd7a17421 |
| Accession Number: |
edsdoj.2fd46867e444490a0207b2fd7a17421 |
| Database: |
Directory of Open Access Journals |
