Longitudinal evidence for a mutually reinforcing relationship between white matter hyperintensities and cortical thickness in cognitively unimpaired older adults

Bibliographic Details
Title:	Longitudinal evidence for a mutually reinforcing relationship between white matter hyperintensities and cortical thickness in cognitively unimpaired older adults
Authors:	Jose Bernal, Inga Menze, Renat Yakupov, Oliver Peters, Julian Hellmann-Regen, Silka Dawn Freiesleben, Josef Priller, Eike Jakob Spruth, Slawek Altenstein, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Björn H. Schott, Frank Jessen, Ayda Rostamzadeh, Wenzel Glanz, Enise I. Incesoy, Katharina Buerger, Daniel Janowitz, Michael Ewers, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Christoph Laske, Sebastian Sodenkamp, Annika Spottke, Anna Esser, Falk Lüsebrink, Peter Dechent, Stefan Hetzer, Klaus Scheffler, Stefanie Schreiber, Emrah Düzel, Gabriel Ziegler
Source:	Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-14 (2024)
Publisher Information:	BMC, 2024.
Publication Year:	2024
Collection:	LCC:Neurosciences. Biological psychiatry. Neuropsychiatry LCC:Neurology. Diseases of the nervous system
Subject Terms:	White Matter Hyperintensities, Cortical Thickness, Latent Growth Curve Model, Longitudinal Modelling, Structural Magnetic Resonance Imaging, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
More Details:	Abstract Background For over three decades, the concomitance of cortical neurodegeneration and white matter hyperintensities (WMH) has sparked discussions about their coupled temporal dynamics. Longitudinal studies supporting this hypothesis nonetheless remain scarce. Methods We applied global and regional bivariate latent growth curve modelling to determine the extent to which WMH and cortical thickness were interrelated over a four-year period. For this purpose, we leveraged longitudinal MRI data from 451 cognitively unimpaired participants (DELCODE; median age 69.71 [IQR 65.51, 75.50] years; 52.32% female). Participants underwent MRI sessions annually over a four-year period (1815 sessions in total, with roughly four MRI sessions per participant). We adjusted all models for demographics and cardiovascular risk. Results Our findings were three-fold. First, larger WMH volumes were linked to lower cortical thickness (σ = -0.165, SE = 0.047, Z = -3.515, P
Document Type:	article
File Description:	electronic resource
Language:	English
ISSN:	1758-9193
Relation:	https://doaj.org/toc/1758-9193
DOI:	10.1186/s13195-024-01606-5
Access URL:	https://doaj.org/article/2fc8b02963e64d939d0391d39c8e28cb
Accession Number:	edsdoj.2fc8b02963e64d939d0391d39c8e28cb
Database:	Directory of Open Access Journals
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More Details
ISSN:	17589193
DOI:	10.1186/s13195-024-01606-5
Published in:	Alzheimer’s Research & Therapy
Language:	English