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IDH1 inhibitor-induced neutrophilic dermatosis in a patient with acute myeloid leukemia

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Title: IDH1 inhibitor-induced neutrophilic dermatosis in a patient with acute myeloid leukemia
Authors: Sydney Dunn-Valadez, Srilakshmi Bathini, Carly Elston, Sravanti Rangaraju, Antonio Di Stasi, Sarah Worth, Diana Morlote, Shuko Harada, Pankit Vachhani
Source: Cancer Treatment and Research Communications, Vol 31, Iss , Pp 100560- (2022)
Publisher Information: Elsevier, 2022.
Publication Year: 2022
Collection: LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Subject Terms: IDH1, Ivosidenib, Differentiation syndrome, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
More Details: Ivosidenib is an oral inhibitor of mutant Isocitrate dehydrogenase 1 (IDH1). It is approved for treatment of patients with relapsed or refractory IDH1-mutated acute myeloid leukemia (AML) and patients with newly diagnosed IDH1-mutated AML who are 75 years or older or those who are ineligible to receive intensive chemotherapy. While generally well tolerated, differentiation syndrome has been reported in 15–20% of patients. Here, we report a case of acute febrile neutrophilic dermatosis or Sweet's syndrome in conjunction with the use of ivosidenib for the treatment of relapsed AML. We discuss the clinical presentation of this rare entity, review relevant literature, and comment on its association with differentiation syndrome.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2468-2942
Relation: http://www.sciencedirect.com/science/article/pii/S2468294222000508; https://doaj.org/toc/2468-2942
DOI: 10.1016/j.ctarc.2022.100560
Access URL: https://doaj.org/article/2fa1bcd8c31444e0bc126a135dcd519a
Accession Number: edsdoj.2fa1bcd8c31444e0bc126a135dcd519a
Database: Directory of Open Access Journals
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  Data: IDH1 inhibitor-induced neutrophilic dermatosis in a patient with acute myeloid leukemia
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  Data: <searchLink fieldCode="AR" term="%22Sydney+Dunn-Valadez%22">Sydney Dunn-Valadez</searchLink><br /><searchLink fieldCode="AR" term="%22Srilakshmi+Bathini%22">Srilakshmi Bathini</searchLink><br /><searchLink fieldCode="AR" term="%22Carly+Elston%22">Carly Elston</searchLink><br /><searchLink fieldCode="AR" term="%22Sravanti+Rangaraju%22">Sravanti Rangaraju</searchLink><br /><searchLink fieldCode="AR" term="%22Antonio+Di+Stasi%22">Antonio Di Stasi</searchLink><br /><searchLink fieldCode="AR" term="%22Sarah+Worth%22">Sarah Worth</searchLink><br /><searchLink fieldCode="AR" term="%22Diana+Morlote%22">Diana Morlote</searchLink><br /><searchLink fieldCode="AR" term="%22Shuko+Harada%22">Shuko Harada</searchLink><br /><searchLink fieldCode="AR" term="%22Pankit+Vachhani%22">Pankit Vachhani</searchLink>
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  Data: Cancer Treatment and Research Communications, Vol 31, Iss , Pp 100560- (2022)
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  Data: Ivosidenib is an oral inhibitor of mutant Isocitrate dehydrogenase 1 (IDH1). It is approved for treatment of patients with relapsed or refractory IDH1-mutated acute myeloid leukemia (AML) and patients with newly diagnosed IDH1-mutated AML who are 75 years or older or those who are ineligible to receive intensive chemotherapy. While generally well tolerated, differentiation syndrome has been reported in 15–20% of patients. Here, we report a case of acute febrile neutrophilic dermatosis or Sweet's syndrome in conjunction with the use of ivosidenib for the treatment of relapsed AML. We discuss the clinical presentation of this rare entity, review relevant literature, and comment on its association with differentiation syndrome.
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  Data: http://www.sciencedirect.com/science/article/pii/S2468294222000508; https://doaj.org/toc/2468-2942
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