Protective effect of interferon-based antiviral therapy on risk of bipolar disorder in patients with hepatitis C Virus infection: A nationwide longitudinal study
| Title: | Protective effect of interferon-based antiviral therapy on risk of bipolar disorder in patients with hepatitis C Virus infection: A nationwide longitudinal study |
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| Authors: | Mu- Hong Chen, Shih- Jen Tsai, Tzeng- Ji Chen |
| Source: | Taiwanese Journal of Psychiatry, Vol 36, Iss 4, Pp 182-187 (2022) |
| Publisher Information: | Wolters Kluwer Medknow Publications, 2022. |
| Publication Year: | 2022 |
| Collection: | LCC:Psychiatry |
| Subject Terms: | depression, inflammation, temporal association, the taiwan national health insurance research database, Psychiatry, RC435-571 |
| More Details: | Background: A recent study has shown the beneficial effects of interferon (IFN)-based antiviral therapy (AVT) in reducing the risk of newly diagnosed depression among patients with hepatitis C virus (HCV) infection. But whether IFN-based AVT reduces the risk of bipolar disorder remains unknown. Methods: This is a retrospective study based on the Taiwan National Health Insurance Research Database. From enrollment to the end of 2013, 24,240 patients with HCV infection (4473 treated with IFN-based AVT and 19,767 without such treatment) as well as 96,960 age- and sex-matched controls were included in this study. Time-dependent Cox regression models were used to study the differences in risk of newly-diagnosed bipolar disorder between patients being treated with and without IFN-based AVT and the control participants. Results: Patients with HCV infection who had not yet received IFN-based AVT (hazard ratio = 4.86, 95% confidence interval = 1.87–12.66, p = 0.001), but not those who were receiving IFN-based AVT (1.69, 0.94 - 30.50, nonsignificance) and those who completed the IFN-based AVT (1.77, 0.69 - 4.54, nonsignificance), were significantly more to be diagnosed with bipolar disorder compared with the control group. Conclusion: Our study supports the temporal association between HCV infection and subsequent bipolar disorder, further suggesting that the optimal AVT to eradicate HCV may be associated with a reduced risk of incident bipolar disorder later in life. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1028-3684 2666-2078 |
| Relation: | http://www.e-tjp.org/article.asp?issn=1028-3684;year=2022;volume=36;issue=4;spage=182;epage=187;aulast=Chen; https://doaj.org/toc/1028-3684; https://doaj.org/toc/2666-2078 |
| DOI: | 10.4103/TPSY.TPSY_37_22 |
| Access URL: | https://doaj.org/article/2f319f3534c44c3387f6f79b1800c05f |
| Accession Number: | edsdoj.2f319f3534c44c3387f6f79b1800c05f |
| Database: | Directory of Open Access Journals |
| ISSN: | 10283684 26662078 |
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| DOI: | 10.4103/TPSY.TPSY_37_22 |
| Published in: | Taiwanese Journal of Psychiatry |
| Language: | English |