Bibliographic Details
| Title: |
Tracing the origin and northward dissemination dynamics of HIV-1 subtype C in Brazil. |
| Authors: |
Edson Delatorre, José C Couto-Fernandez, Monick Lindenmayer Guimarães, Ludimila Paula Vaz Cardoso, Keila Correia de Alcantara, Mariane Martins de Araújo Stefani, Hector Romero, Caio C M Freire, Atila Iamarino, Paolo M de A Zanotto, Mariza G Morgado, Gonzalo Bello |
| Source: |
PLoS ONE, Vol 8, Iss 9, p e74072 (2013) |
| Publisher Information: |
Public Library of Science (PLoS), 2013. |
| Publication Year: |
2013 |
| Collection: |
LCC:Medicine
LCC:Science |
| Subject Terms: |
Medicine, Science |
| More Details: |
Previous studies indicate that the HIV-1 subtype C epidemic in southern Brazil was initiated by the introduction of a single founder strain probably originating from east Africa. However, the exact country of origin of such a founder strain as well as the origin of the subtype C viruses detected outside the Brazilian southern region remains unknown. HIV-1 subtype C pol sequences isolated in the southern, southeastern and central-western Brazilian regions (n = 209) were compared with a large number (n ~ 2,000) of subtype C pol sequences of African origin. Maximum-likelihood analyses revealed that most HIV-1 subtype C Brazilian sequences branched in a single monophyletic clade (CBR-I), nested within a larger monophyletic lineage characteristic of east Africa. Bayesian analyses indicate that the CBR-I clade most probably originated in Burundi and was introduced into the Paraná state (southern region) around the middle 1970s, after which it rapidly disseminated to neighboring regions. The states of Paraná and Santa Catarina have been the most important hubs of subtype C dissemination, and routine travel and spatial accessibility seems to have been the major driving forces of this process. Five additional introductions of HIV-1 subtype C strains probably originated in eastern (n = 2), southern (n = 2) and central (n = 1) African countries were detected in the Rio de Janeiro state (southeastern region). These results indicate a continuous influx of HIV-1 subtype C strains of African origin into Brazil and also unveil the existence of unrecognized transmission networks linking this country to east Africa. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1932-6203 |
| Relation: |
http://europepmc.org/articles/PMC3771961?pdf=render; https://doaj.org/toc/1932-6203 |
| DOI: |
10.1371/journal.pone.0074072 |
| Access URL: |
https://doaj.org/article/2f0beb8abcbb49d19fb6d54d8e8a6b15 |
| Accession Number: |
edsdoj.2f0beb8abcbb49d19fb6d54d8e8a6b15 |
| Database: |
Directory of Open Access Journals |
