Bibliographic Details
| Title: |
Examining Outcomes in Patients Admitted With Comorbid Peripheral Artery Disease and Microvascular Disease |
| Authors: |
Scott Grubman, Miguel Algara, Kim G. Smolderen, Paulina Luna, Kristie Walenczyk, Lindsey Scierka, Jacob Cleman, Waleed Tariq Siddiqui, Gaëlle Romain, Carlos Mena‐Hurtado |
| Source: |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 1 (2024) |
| Publisher Information: |
Wiley, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Diseases of the circulatory (Cardiovascular) system |
| Subject Terms: |
amputations, microvascular disease, mortality, peripheral artery disease, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| More Details: |
Background Peripheral artery disease (PAD) and microvascular disease (MVD) are highly prevalent conditions that share common risk factors. This observational study aimed to characterize patients with both conditions and determine the impact of comorbid PAD/MVD on outcomes. Methods and Results Patients admitted across 31 states January 2011 through December 2018 with a primary or secondary diagnosis of PAD or MVD were included from the National Readmissions Database and weighted to approximate a national sample. Those age 500 000 in 2018. Major and minor amputations increased ≈50% for PAD/MVD between 2011 and 2018. Compared with PAD‐only, PAD/MVD was associated with a higher risk for major amputation (odds ratio [OR], 1.30 [95% CI, 1.28–1.32]), minor amputation (OR, 2.15 [95% CI, 2.12–2.18]), major adverse cardiac events (OR, 1.04 [95% CI, 1.03–1.04]), in‐hospital mortality (OR, 1.07 [95% CI, 1.05–1.09]), and readmission (hazard ratio, 1.02 [95% CI, 1.02–1.02]) after adjustment for baseline factors. Conclusions Comorbid MVD is present in a large and growing number of patients with PAD and is associated with augmented risk for adverse outcomes. Further prospective research is merited to understand this vulnerable population. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2047-9980 |
| Relation: |
https://doaj.org/toc/2047-9980 |
| DOI: |
10.1161/JAHA.123.030710 |
| Access URL: |
https://doaj.org/article/2ef876486e2e4367b4f819b4733eb363 |
| Accession Number: |
edsdoj.2ef876486e2e4367b4f819b4733eb363 |
| Database: |
Directory of Open Access Journals |
