Plasminogen-derived peptide promotes adipogenic differentiation of preadipocytes in vitro and in vivo
| Title: | Plasminogen-derived peptide promotes adipogenic differentiation of preadipocytes in vitro and in vivo |
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| Authors: | Hea Jung Yang, Jong-Ho Kim, Jung Hee Shim, Chan Yeong Heo |
| Source: | Adipocyte, Vol 11, Iss 1, Pp 643-652 (2022) |
| Publisher Information: | Taylor & Francis Group, 2022. |
| Publication Year: | 2022 |
| Collection: | LCC:Diseases of the endocrine glands. Clinical endocrinology LCC:Cytology LCC:Physiology |
| Subject Terms: | Adipose-derived stem cell (ADSC), breast cancer, differentiation, peptide, plasminogen (PLG), Diseases of the endocrine glands. Clinical endocrinology, RC648-665, Cytology, QH573-671, Physiology, QP1-981 |
| More Details: | ABSTRACTSoft tissue defects caused by adipose tissue loss can result in various conditions such as lipodystrophy in congenital diseases, trauma secondary to ageing, and mastectomy in breast cancer; fat grafting is commonly performed to restore these defects. Although various enrichment strategies have been studied, novel therapeutics that are cost-effective, safe, technologically easy to manufacture, and minimally invasive are required. In this study, we identified a novel peptide derived from plasminogen, named plasminogen-derived peptide-1 (PLP-1), which showed adipogenic differentiation potential and led to an increase in the expression levels of adiponectin, C1Q and collagen domain containing protein, fatty acid-binding protein 4, and CCAAT/enhancer-binding protein-alpha. In vivo experiments confirmed an increase in the rate of adipocyte differentiation and the expression levels of CD31 in the PLP-1-treated mice groups. These results suggested that PLP-1 plays an important role in promoting the differentiation of preadipocytes and may be useful for developing therapeutic approaches to treat adipose tissue defects. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 21623945 2162-397X 2162-3945 |
| Relation: | https://doaj.org/toc/2162-3945; https://doaj.org/toc/2162-397X |
| DOI: | 10.1080/21623945.2022.2149121 |
| Access URL: | https://doaj.org/article/e2ed1ff317f2418aadf638bcb52c2c30 |
| Accession Number: | edsdoj.2ed1ff317f2418aadf638bcb52c2c30 |
| Database: | Directory of Open Access Journals |
| ISSN: | 21623945 2162397X |
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| DOI: | 10.1080/21623945.2022.2149121 |
| Published in: | Adipocyte |
| Language: | English |