Bibliographic Details
| Title: |
The Clinical Significance of HLA Compatibility Scores in Lung Transplantation |
| Authors: |
Liesbeth Daniëls, Hanne Beeckmans, Andrea Zajacova, Pieterjan Kerckhof, Saskia Bos, Maarten Naesens, Bart Vanaudenaerde, Frans Claas, Robin Vos |
| Source: |
Transplant International, Vol 37 (2025) |
| Publisher Information: |
Frontiers Media S.A., 2025. |
| Publication Year: |
2025 |
| Collection: |
LCC:Specialties of internal medicine |
| Subject Terms: |
lung transplantation, HLAMatchmaker, HLA-EMMA, PIRCHE-II, KIR ligand calculator, Specialties of internal medicine, RC581-951 |
| More Details: |
Lung transplantation is a life-saving therapeutic option for many chronic end-stage pulmonary diseases, but long-term survival may be limited by rejection of the transplanted organ. Since HLA disparity between donor and recipient plays a major role in rejection, we performed a single center, retrospective observational cohort analysis in our lung transplant cohort (n = 128) in which we calculated HLA compatibility scores for B-cell epitopes (HLAMatchmaker, HLA-EMMA), T-cell epitopes (PIRCHE-II) and missing self-induced NK cell activation (KIR Ligand Calculator). Adjusted Cox proportional hazards model was used to investigate the association between mismatched scores and time to development of donor-specific antibodies (DSA) post-transplant, time to first biopsy-proven acute rejection episode, freedom from CLAD, graft survival and overall survival. For time to first DSA, HLA-EMMA DQB1 scores and PIRCHE-II DQB1 scores were significantly associated with more rapidly developing anti-HLA-DQ antibodies. HLA-EMMA DQB1 score was significantly associated with worse survival. KIR ligand Host-versus-Graft (HvG) mismatches was significantly associated with worse graft survival (CLAD or death) and shorter time to first biopsy-proven rejection when 2 mismatches were present. We demonstrated that HLA-DQB1 compatibility scores and KIR ligand HvG 2 mismatches may allow for identification of recipients at risk of poor long-term outcomes after lung transplantation. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1432-2277 |
| Relation: |
https://www.frontierspartnerships.org/articles/10.3389/ti.2024.13484/full; https://doaj.org/toc/1432-2277 |
| DOI: |
10.3389/ti.2024.13484 |
| Access URL: |
https://doaj.org/article/d2e556774f1e410782e54fe4a943d1e9 |
| Accession Number: |
edsdoj.2e556774f1e410782e54fe4a943d1e9 |
| Database: |
Directory of Open Access Journals |
