Academic Journal
Evaluation of Cardiovascular Risk Profile and Risk Scores of Antiretroviral Therapy-naïve HIV Patients in Eastern India
| Title: | Evaluation of Cardiovascular Risk Profile and Risk Scores of Antiretroviral Therapy-naïve HIV Patients in Eastern India |
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| Authors: | Manaswi Chaubey, Jaya Chakravarty, Rishabh Gupta, Parth Jethwani, Rahul Puri, Shyam Sundar |
| Source: | Journal of Global Infectious Diseases, Vol 16, Iss 3, Pp 104-110 (2024) |
| Publisher Information: | Wolters Kluwer Medknow Publications, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Infectious and parasitic diseases |
| Subject Terms: | antiretroviral therapy, cardiovascular disease, cardiovascular disease risk, cardiovascular risk score, human immunodeficiency virus, people living with human immunodeficiency virus, Infectious and parasitic diseases, RC109-216 |
| More Details: | Introduction: People living with human immunodeficiency virus (PLHIV) are known to have an increased prevalence of traditional cardiovascular risk factors and are at a higher risk of cardiovascular disease (CVD). This study was done to assess the CVD risk factors in treatment naïve PLHIV in a center of the national program. Methods: In this cross-sectional explorative study, traditional CVD risk factors were assessed, and 10-year Framingham and atherosclerotic cardiovascular disease (ASCVD) risk score were calculated in treatment naïve PLHIV attending the antiretroviral therapy (ART) center, IMS, BHU. Results: The study included 337 ART naïve patients. The prevalence of CVD risk factors in treatment naïve PLHIV - were low high-density lipoprotein cholesterol levels (81.4%), high triglyceride levels (32.7%), smoking (32.3%), obesity (13.6%), hypertension (5%), diabetes (2.7%), and high low-density lipoprotein cholesterol levels (2.1%). Moderate-to-high 10-year Framingham Risk Score and American Heart Association/American College of Cardiology 10-year ASCVD risk score were 10.8% and 8.9%, respectively. In Framingham Risk Score, age ≥40 years (odds ratio [OR] - 131) (95% confidence interval [CI] - 6.5–1043) alcohol intake (OR - 5.14 [95% CI - 1.82–14.46] and presence of tuberculosis (OR - 4.78) (95% CI - 1.48-15.40), while in ASCVD risk score history of alcohol intake (OR - 26.20 [95% CI - 3.1-216.8] were at higher risk of CVD in multivariate variate analysis. Conclusion: CVD risk factors were common among ART naïve patient. Thus, screening, education, and treatment of CVD risk factors should be done in these patients at initiation of care. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 0974-777X 0974-8245 |
| Relation: | https://journals.lww.com/10.4103/jgid.jgid_29_24; https://doaj.org/toc/0974-777X; https://doaj.org/toc/0974-8245 |
| DOI: | 10.4103/jgid.jgid_29_24 |
| Access URL: | https://doaj.org/article/2e00a70cd58c433ea60c0f51f8a4445b |
| Accession Number: | edsdoj.2e00a70cd58c433ea60c0f51f8a4445b |
| Database: | Directory of Open Access Journals |
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| ISSN: | 0974777X 09748245 |
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| DOI: | 10.4103/jgid.jgid_29_24 |
| Published in: | Journal of Global Infectious Diseases |
| Language: | English |