Bibliographic Details
| Title: |
Current knowledge on the role of extracellular vesicles in endometrial receptivity |
| Authors: |
Cong Sui, Zhiqi Liao, Jian Bai, Dan Hu, Jing Yue, Shulin Yang |
| Source: |
European Journal of Medical Research, Vol 28, Iss 1, Pp 1-14 (2023) |
| Publisher Information: |
BMC, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Medicine |
| Subject Terms: |
Endometrial receptivity, Embryo implantation, Extracellular vesicles, Non-invasive biomarker, Therapeutic mediator, Medicine |
| More Details: |
Abstract Endometrial receptivity has been widely understood as the capacity of the endometrium to receive implantable embryos. The establishment of endometrial receptivity involves multiple biological processes including decidualization, tissue remodeling, angiogenesis, immune regulation, and oxidative metabolism. Extracellular vesicles (EVs) are lipid-bilayer-membrane nanosized vesicles mediating cell-to-cell communication. Recently, EVs and their cargo have been proven as functional factors in the establishment of endometrial receptivity. In this review, we comprehensively summarized the alteration of endometrium/embryo-derived EVs during the receptive phase and retrospected the current findings which revealed the pivotal role and potential mechanism of EVs to promote successful implantation. Furthermore, we highlight the potentiality and limitations of EVs being translated into clinical applications such as biomarkers of endometrial receptivity or reproductive therapeutic mediators, and point out the direction for further research. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2047-783X |
| Relation: |
https://doaj.org/toc/2047-783X |
| DOI: |
10.1186/s40001-023-01459-y |
| Access URL: |
https://doaj.org/article/2dd0bc330a0a47488cf9bf3ed245322b |
| Accession Number: |
edsdoj.2dd0bc330a0a47488cf9bf3ed245322b |
| Database: |
Directory of Open Access Journals |
