Characteristics of uterine bleeding associated with an oral contraceptive containing drospirenone in combination with estetrol: A multicenter observational study
| Title: | Characteristics of uterine bleeding associated with an oral contraceptive containing drospirenone in combination with estetrol: A multicenter observational study |
|---|---|
| Authors: | Irina V. Kuznetsova, Liudmila V. Evsyukova |
| Source: | Гинекология, Vol 26, Iss 3, Pp 210-215 (2024) |
| Publisher Information: | IP Berlin A.V., 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Gynecology and obstetrics |
| Subject Terms: | combined hormonal contraception, side effects, bleeding pattern, estetrol, drospirenone, esteretta, Gynecology and obstetrics, RG1-991 |
| More Details: | Background. An unfavorable bleeding pattern is a common reason for refusing to continue hormonal contraception. Aim. To evaluate the characteristics of uterine bleeding when using a new combined oral contraceptive (COC) containing estetrol and drospirenone (Esteretta®). Materials and methods. A multicenter observational study included 1402 females aged 18–49 who received Esteretta® for 6 cycles. The frequency, duration, and severity of withdrawal bleeding, as well as the frequency of unpredictable bleeding, were assessed. Results. The rate of regular withdrawal bleeding was 100%. The proportion of women with heavy menstruation/withdrawal bleeding decreased from 29.6 to 10.07% (p0.0001). The duration of regular withdrawal bleeding was significantly reduced (p=0.008). The incidence of unpredictable bleeding during COC use decreased from 4.57 to 3.29% (p=0.05). Satisfactory cycle control was observed in 87.43% of women. 2.5% of participants refused to continue using COCs. Conclusion. Esteretta® provides a high rate of regular withdrawal bleeding and a low rate of unpredictable bleeding. Given the optimal safety profile, this drug may be the first choice for contraception in sexually active women who are not planning a pregnancy. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | Russian |
| ISSN: | 2079-5696 2079-5831 20795696 |
| Relation: | https://gynecology.orscience.ru/2079-5831/article/viewFile/636221/151490; https://doaj.org/toc/2079-5696; https://doaj.org/toc/2079-5831 |
| DOI: | 10.26442/20795696.2024.3.202968 |
| Access URL: | https://doaj.org/article/2c9dd53c93b3478e8d7edc566fbaa8a6 |
| Accession Number: | edsdoj.2c9dd53c93b3478e8d7edc566fbaa8a6 |
| Database: | Directory of Open Access Journals |
| ISSN: | 20795696 20795831 |
|---|---|
| DOI: | 10.26442/20795696.2024.3.202968 |
| Published in: | Гинекология |
| Language: | Russian |