| Title: |
High prevalence of SARS-CoV-2 antibodies in pregnant women after the second wave of infections in the inner-city of Johannesburg, Gauteng Province, South Africa |
| Authors: |
Shobna Sawry, Jean Le Roux, Nicole Wolter, Philile Mbatha, Jinal Bhiman, Jennifer Balkus, Anne von Gottberg, Cheryl Cohen, Matthew Chersich, Malolo Kekana, Thatcher Ndlovu, Angela Shipalana, Wendy Mthimunye, Faeezah Patel, Hermien Gous, Sibongile Walaza, Stefano Tempia, Helen Rees, Lee Fairlie |
| Source: |
International Journal of Infectious Diseases, Vol 125, Iss , Pp 241-249 (2022) |
| Publisher Information: |
Elsevier, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Infectious and parasitic diseases |
| Subject Terms: |
SARS-CoV-2 seroprevalence, Serosurveys, HIV, South Africa, COVID-19, Pregnant women, Infectious and parasitic diseases, RC109-216 |
| More Details: |
Objectives: After South Africa's second wave of COVID-19, this study estimated the SARS-CoV-2 seroprevalence among pregnant women in inner-city Johannesburg, South Africa. Methods: In this cross-sectional survey, 500 pregnant women who were non-COVID-19-vaccinated (aged ≥12 years) were enrolled, and demographic and clinical data were collected. Serum samples were tested using the Wantai SARS-CoV-2 spike antibody enzyme-linked immunosorbent assay and Roche Elecsys® anti-SARS-CoV-2 nucleocapsid antibody assays. Seropositivity was defined as SARS-CoV-2 antibodies on either (primary) or both (secondary) assays. Univariate Poisson regression assessed risk factors associated with seropositivity. Results: The median age was 27.4 years, and HIV prevalence was 26.7%. SARS-CoV-2 seroprevalence was 64.0% (95% confidence interval [CI]: 59.6-68.2%) on the primary and 54% (95% CI: 49.5-58.4%) on the secondary measure. Most (96.6%) women who were SARS-CoV-2-seropositive reported no symptoms. On the Roche assay, we detected lower seroprevalence among women living with HIV than women without HIV (48.9% vs 61.7%, P-value = 0.018), and especially low levels among women living with HIV with a clusters of differentiation 4 |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1201-9712 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S1201971222005756; https://doaj.org/toc/1201-9712 |
| DOI: |
10.1016/j.ijid.2022.10.036 |
| Access URL: |
https://doaj.org/article/2c2e394a568b44c88e1ee18c00e7ca34 |
| Accession Number: |
edsdoj.2c2e394a568b44c88e1ee18c00e7ca34 |
| Database: |
Directory of Open Access Journals |
