Academic Journal

Long‐term remission of small cell lung cancer after reactivation of tuberculosis following immune‐checkpoint blockade: A case report

Bibliographic Details
Title:	Long‐term remission of small cell lung cancer after reactivation of tuberculosis following immune‐checkpoint blockade: A case report
Authors:	Mattia Sirgiovanni, Clemens Hinterleitner, Marius Horger, Naushad Bijoy Atique, Ulrich M. Lauer, Lars Zender, Martina Hinterleitner
Source:	Thoracic Cancer, Vol 12, Iss 5, Pp 699-702 (2021)
Publisher Information:	Wiley, 2021.
Publication Year:	2021
Collection:	LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Subject Terms:	immune‐checkpoint inhibitors, lung cancer, PD‐L1, tuberculosis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
More Details:	Abstract Immune‐checkpoint inhibitors (ICIs) provide a promising treatment option for advanced tumors including small cell lung cancer (SCLC). Nevertheless, in addition to immune‐related adverse events (irAEs), an increased risk of infection including tuberculosis has been previously described. Here, we report a case of long‐term remission of a patient with SCLC after reactivation of lung tuberculosis following ICI therapy. Our case illustrates the complexity of ICI‐associated immune modulation in tuberculosis. Since new lesions in lung cancer patients are commonly associated with tumor progression, infections with mycobacterial tuberculosis may be underdiagnosed in lung cancer.
Document Type:	article
File Description:	electronic resource
Language:	English
ISSN:	1759-7714 1759-7706
Relation:	https://doaj.org/toc/1759-7706; https://doaj.org/toc/1759-7714
DOI:	10.1111/1759-7714.13821
Access URL:	https://doaj.org/article/2c156fed30e849c2961ad2aac761a37e
Accession Number:	edsdoj.2c156fed30e849c2961ad2aac761a37e
Database:	Directory of Open Access Journals

More Details
ISSN:	17597714 17597706
DOI:	10.1111/1759-7714.13821
Published in:	Thoracic Cancer
Language:	English