Bibliographic Details
| Title: |
The relationship between metabolic dysfunction-associated fatty liver disease and the incidence rate of extrahepatic cancer |
| Authors: |
Suosu Wei, Yanrong Hao, Xiaofeng Dong, Junzhang Huang, Kai Huang, Yujie Xie, Hongjun Liu, Chunyu Wei, Jinan Xu, Wei Huang, Lingguang Dong, Jianrong Yang |
| Source: |
Frontiers in Endocrinology, Vol 14 (2023) |
| Publisher Information: |
Frontiers Media S.A., 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Diseases of the endocrine glands. Clinical endocrinology |
| Subject Terms: |
MAFLD, cancer, metabolic dysfunction, fatty liver disease, incidence rate, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| More Details: |
BackgroundThe associations between metabolic dysfunction-associated fatty liver disease (MAFLD) and cancer development, especially extrahepatic cancers, are unknown. The aims of the current study were to investigate the cancer incidence rates of MAFLD and analyze the associations between MAFLD and the development of cancers.MethodsThis historical cohort study included participants who underwent ultrasonographic detection of hepatic steatosis at a tertiary hospital in China from January 2013 to October 2021. MAFLD was diagnosed in accordance with The International Expert Consensus Statement. Cox proportional hazards regression modeling was used to assess the associations between MAFLD and the development of cancers.ResultsOf the 47,801 participants, 16,093 (33.7%) had MAFLD. During the total follow-up of 175,137 person-years (median 3.3 years), the cancer incidence rate in the MAFLD group was higher than that in the non-MAFLD group [473.5 vs. 255.1 per 100,000 person-years; incidence rate ratio 1.86; 95% confidence interval (CI) 1.57–2.19]. After adjustment for age, gender, smoking status, and alcohol status, MAFLD was moderately associated with cancers of the female reproductive system/organs (labium, uterus, cervix, and ovary) [hazard ratio (HR) 2.24; 95% CI 1.09–4.60], thyroid (HR 3.64; 95% CI 1.82–7.30), and bladder (HR 4.19; 95% CI 1.15–15.27) in the total study cohort.ConclusionMAFLD was associated with the development of cancers of the female reproductive system/organs (labium, uterus, cervix, and ovary), thyroid, and bladder in the total study cohort. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1664-2392 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fendo.2023.985858/full; https://doaj.org/toc/1664-2392 |
| DOI: |
10.3389/fendo.2023.985858 |
| Access URL: |
https://doaj.org/article/2c13482d18b2454a86ec1f170b95178b |
| Accession Number: |
edsdoj.2c13482d18b2454a86ec1f170b95178b |
| Database: |
Directory of Open Access Journals |
