Bibliographic Details
| Title: |
Secondary Metabolites from Vietnamese Marine Invertebrates with Activity against Trypanosoma brucei and T. cruzi |
| Authors: |
Nguyen Phuong Thao, Joo Hwan No, Bui Thi Thuy Luyen, Gyongseon Yang, Soo Young Byun, Junghyun Goo, Kyung Tae Kim, Nguyen Xuan Cuong, Nguyen Hoai Nam, Chau Van Minh, Thomas J. Schmidt, Jong Seong Kang, Young Ho Kim |
| Source: |
Molecules, Vol 19, Iss 6, Pp 7869-7880 (2014) |
| Publisher Information: |
MDPI AG, 2014. |
| Publication Year: |
2014 |
| Collection: |
LCC:Organic chemistry |
| Subject Terms: |
soft coral, echinoderm, marine natural product, Trypanosoma brucei, Trypanosoma cruzi, neglected tropical diseases, Organic chemistry, QD241-441 |
| More Details: |
Marine-derived natural products from invertebrates comprise an extremely diverse and promising source of the compounds from a wide variety of structural classes. This study describes the discovery of five marine natural products with activity against Trypanosoma species by natural product library screening using whole cell in vitro assays. We investigated the anti-trypanosomal activity of the extracts from the soft corals and echinoderms living in Vietnamese seas. Of the samples screened, the methanolic extracts of several marine organisms exhibited potent activities against cultures of Trypanosoma brucei and T. cruzi (EC50 < 5.0 μg/mL). Among the compounds isolated from these extracts, laevigatol B (1) from Lobophytum crassum and L. laevigatum, (24S)-ergost-4-ene-3-one (2) from Sinularia dissecta, astropectenol A (3) from Astropecten polyacanthus, and cholest-8-ene-3β,5α,6β,7α-tetraol (4) from Diadema savignyi showed inhibitory activity against T. brucei with EC50 values ranging from 1.57 ± 0.14 to 14.6 ± 1.36 μM, relative to the positive control, pentamidine (EC50 = 0.015 ± 0.003 μM). Laevigatol B (1) and 5α-cholest-8(14)-ene-3β,7α-diol (5) exhibited also significant inhibitory effects on T. cruzi. The cytotoxic activity of the pure compounds on mammalian cells was also assessed and found to be insignificant in all cases. This is the first report on the inhibitory effects of marine organisms collected in Vietnamese seas against Trypanosoma species responsible for neglected tropical diseases. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1420-3049 |
| Relation: |
http://www.mdpi.com/1420-3049/19/6/7869; https://doaj.org/toc/1420-3049 |
| DOI: |
10.3390/molecules19067869 |
| Access URL: |
https://doaj.org/article/2c093cb5e39c4d458f2663b27154af8f |
| Accession Number: |
edsdoj.2c093cb5e39c4d458f2663b27154af8f |
| Database: |
Directory of Open Access Journals |
