Bibliographic Details
| Title: |
Multivariate genome-wide association study of depression, cognition, and memory phenotypes and validation analysis identify 12 cross-ethnic variants |
| Authors: |
Jing Sun, Weijing Wang, Ronghui Zhang, Haiping Duan, Xiaocao Tian, Chunsheng Xu, Xue Li, Dongfeng Zhang |
| Source: |
Translational Psychiatry, Vol 12, Iss 1, Pp 1-10 (2022) |
| Publisher Information: |
Nature Publishing Group, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| Subject Terms: |
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| More Details: |
Abstract To date, little is known about the pleiotropic genetic variants among depression, cognition, and memory. The current research aimed to identify the potential pleiotropic single nucleotide polymorphisms (SNPs), genes, and pathways of the three phenotypes by conducting a multivariate genome-wide association study and an additional pleiotropy analysis among Chinese individuals and further validate the top variants in the UK Biobank (UKB). In the discovery phase, the participants were 139 pairs of dizygotic twins from the Qingdao Twins Registry. The genome-wide efficient mixed-model analysis identified 164 SNPs reaching suggestive significance (P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2158-3188 |
| Relation: |
https://doaj.org/toc/2158-3188 |
| DOI: |
10.1038/s41398-022-02074-x |
| Access URL: |
https://doaj.org/article/ca2bbd61bd7e4ee6822ef49cd4814646 |
| Accession Number: |
edsdoj.2bbd61bd7e4ee6822ef49cd4814646 |
| Database: |
Directory of Open Access Journals |
