Analysis of early efficacy and immune reconstitution after autologous hematopoietic stem cell transplantation in multiple myeloma

Bibliographic Details
Title:	Analysis of early efficacy and immune reconstitution after autologous hematopoietic stem cell transplantation in multiple myeloma
Authors:	Kaili Chen, Huixin Liang, Zezhong Yu, Guangyao Guo, Huijian Zheng, Yun Huang, Liping Liu, Jie Lin, Jinlan Long, Renyao Pan, Xi Chen, Changgui Wang, Wenjie Zhang, Zhenshu Xu
Source:	Scientific Reports, Vol 15, Iss 1, Pp 1-12 (2025)
Publisher Information:	Nature Portfolio, 2025.
Publication Year:	2025
Collection:	LCC:Medicine LCC:Science
Subject Terms:	Multiple myeloma, Autologous hematopoietic stem cell transplantation, Efficacy analysis, Immune reconstitution, Medicine, Science
More Details:	Abstract This retrospective study aimed to stress the advantages of autologous hematopoietic stem cell transplantation (auto-HSCT) in treating primary MM. Ninety-four MM patients who underwent initial parallel sequential auto-HSCT were selected. Data on efficacy (efficacy evaluation, renal function and hemoglobin recovery), immune reconstitution (B-cell subsets, immunoglobulin levels, T-cell subsets, NK cells, neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR)) and hematopoietic reconstitution times were collected and analyzed. Whether in all selected patients or in groups R-ISS II-III, there was a notable increase in the proportion of patients achieving in a very good partial response (VGPR) or better (P
Document Type:	article
File Description:	electronic resource
Language:	English
ISSN:	2045-2322
Relation:	https://doaj.org/toc/2045-2322
DOI:	10.1038/s41598-024-84047-2
Access URL:	https://doaj.org/article/a2b4c969b5dc4be480bc8d2e00a00bc5
Accession Number:	edsdoj.2b4c969b5dc4be480bc8d2e00a00bc5
Database:	Directory of Open Access Journals
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More Details
ISSN:	20452322
DOI:	10.1038/s41598-024-84047-2
Published in:	Scientific Reports
Language:	English