Vitamin D as a predictor of clinical response among patients with cardiac resynchronization therapy (CRT)
| Title: | Vitamin D as a predictor of clinical response among patients with cardiac resynchronization therapy (CRT) |
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| Authors: | Phuuwadith Wattanachayakul, Thitiphan Srikulmontri, Vitchapong Prasitsumrit, Thanathip Suenghataiphorn, Pojsakorn Danpanichkul, Natchaya Polpichai, Sakditad Saowapa, Abiodun Idowu, Aman Amanullah |
| Source: | Journal of Arrhythmia, Vol 40, Iss 4, Pp 975-981 (2024) |
| Publisher Information: | Wiley, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Diseases of the circulatory (Cardiovascular) system |
| Subject Terms: | 25‐hydroxy vitamin D, cardiac resynchronization therapy, meta‐analysis, systematic review, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| More Details: | Abstract Introduction Cardiovascular and noncardiovascular comorbidities have been recognized as predictors of clinical response in patients receiving cardiac resynchronization therapy (CRT). However, data on vitamin D as a predictor of CRT response are conflicting. Method We identified studies from MEDLINE and Embase databases, searching from inception to May 2024, to investigate the association between 25‐OH vitamin D levels before CRT implantation and outcomes. Studies had to report 25‐OH vitamin D levels or the proportion of patients with vitamin D insufficiency and categorize outcomes as CRT responders or nonresponders. We extracted mean 25‐OH vitamin D and standard deviations for both groups from each study and calculated the pooled mean difference (MD). We also retrieved risk ratios, and 95% confidence intervals (CIs) for the association between vitamin D insufficiency and lack of CRT response, combining them using the generic inverse variance method. Results Our meta‐analysis included four studies. CRT responders had higher levels of 25‐OH vitamin D than nonresponders, with a pooled MD of 8.04 ng/mL (95% CI: 3.16–12.93; I2 = 48%, p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1883-2148 1880-4276 |
| Relation: | https://doaj.org/toc/1880-4276; https://doaj.org/toc/1883-2148 |
| DOI: | 10.1002/joa3.13116 |
| Access URL: | https://doaj.org/article/2b33f8091f9040f0a5546b82786b529f |
| Accession Number: | edsdoj.2b33f8091f9040f0a5546b82786b529f |
| Database: | Directory of Open Access Journals |
| ISSN: | 18832148 18804276 |
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| DOI: | 10.1002/joa3.13116 |
| Published in: | Journal of Arrhythmia |
| Language: | English |